Ivan O Edafiogho
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Explore the profile of Ivan O Edafiogho including associated specialties, affiliations and a list of published articles.
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22
Citations
126
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Recent Articles
1.
Nounou M, Eassa H, Orzechowski K, Eassa H, Edouard J, Stepak N, et al.
Pharmacy (Basel)
. 2022 Jul;
10(4).
PMID: 35893710
Background: Augmented reality (AR) is a technological approach which combines virtual objects such as text, pictures or videos with physical objects (real-world). The study aimed to design, implement and validate...
2.
Ghoneim O, Bill A, Dhuguru J, Szollosi D, Edafiogho I
Bioorg Med Chem
. 2018 Jun;
26(14):3890-3898.
PMID: 29903412
Infection triggers the release of pro-inflammatory cytokines (TNF-alpha and IL-6). Over-production, however, cause tissue injury seen in severe asthma. The ability of enaminone E121 to reduce pro-inflammatory cytokines in our...
3.
Szollosi D, Manzoor M, Aquilato A, Jackson P, Ghoneim O, Edafiogho I
J Pharm Pharmacol
. 2017 Sep;
70(1):18-26.
PMID: 28872680
Objectives: Many studies of disease state mechanisms reveal that unbridled inflammation is to blame for many of the symptoms associated with autoimmune diseases such as Crohn's and Rheumatoid Arthritis (RA)....
4.
Szollosi D, Ghoneim O, Manzoor M, Dhuguru J, Edafiogho I
Inflammation
. 2016 Sep;
39(6):2053-2061.
PMID: 27614763
Pro-inflammatory mediators including TNF-alpha, IL-6, and nitric oxide are important for the regulation of the immune response when an infection is present, but when overproduced, it can be responsible for...
5.
Nashawi H, Masocha W, Edafiogho I, Kombian S
Med Princ Pract
. 2016 Jun;
25(5):423-8.
PMID: 27336416
Objective: The aim of this study was to elucidate any electrophysiological changes that may contribute to the development of neuropathic pain during treatment with the anticancer drug paclitaxel, particularly in...
6.
Masocha W, Kombian S, Edafiogho I
Sci Rep
. 2016 Feb;
6:21582.
PMID: 26916642
Recently, we found that methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate (E139), an anticonvulsant enaminone, has antinociceptive activity in the hot plate test. In this study we evaluated the antinociceptive activity of five anilino enaminones...
7.
Qaddoumi M, Ananthalakshmi K, Phillips O, Edafiogho I, Kombian S
PLoS One
. 2014 Jun;
9(6):e99770.
PMID: 24945912
Epilepsy and other seizure disorders are not adequately managed with currently available drugs. We recently synthesized a series of dibromophenyl enaminones and demonstrated that AK6 and E249 were equipotent to...
8.
Ezeamuzie C, El-Hashim A, Renno W, Edafiogho I
J Pharmacol Exp Ther
. 2014 Jun;
350(2):444-54.
PMID: 24917545
Activation of mast cells and eosinophils is a fundamental process in the pathophysiology of allergic diseases. We have previously reported that the novel enhydrazinone ester CEE-1 (ethyl 4-phenylhydrazinocyclohex-3-en-2-oxo-6-phenyl-1-oate) possesses potent...
9.
Edafiogho I, Qaddoumi M, Ananthalakshmi K, Phillips O, Kombian S
Eur J Med Chem
. 2014 Feb;
76:20-30.
PMID: 24565570
Due to the excellent anticonvulsant activity of previously synthesized halogenated enaminones, more disubstituted analogs were synthesized and evaluated in vitro. The new enaminones either had no effect, depressed, or enhanced...
10.
El-Hashim A, Edafiogho I, Jaffal S, Yousif M, Ezeamuzie C, Kombian S
Life Sci
. 2011 Jul;
89(11-12):378-87.
PMID: 21798272
Aims: In this study, we investigated whether the enaminone, E121, has anti-tussive effects in a guinea pig model of cough, and if so, whether this effect is mediated via a...