Howard C Hang
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Explore the profile of Howard C Hang including associated specialties, affiliations and a list of published articles.
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123
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4600
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Recent Articles
1.
Yang X, Hang H
Bioorg Med Chem
. 2025 Jan;
119:118047.
PMID: 39756344
The emergence of antibiotic-resistant bacteria has intensified the need for novel therapeutic strategies targeting bacterial virulence rather than growth or survival. Bacterial virulence involves complex processes that enable pathogens to...
2.
Yang X, Hang H
Science
. 2024 Nov;
386(6723):eado8548.
PMID: 39541443
Advances in genomics, proteomics, and metabolomics have revealed associations between specific microbiota species in health and disease. However, the precise mechanism(s) of action for many microbiota species and molecules have...
3.
Klupt S, Fam K, Zhang X, Chodisetti P, Mehmood A, Boyd T, et al.
Elife
. 2024 Jun;
13.
PMID: 38857064
is a microbiota species in humans that can modulate host immunity (Griffin and Hang, 2022), but has also acquired antibiotic resistance and is a major cause of hospital-associated infections (Van...
4.
Routy B, Jackson T, Mahlmann L, Baumgartner C, Blaser M, Byrd A, et al.
Cancer Cell
. 2023 Dec;
42(1):16-34.
PMID: 38157864
Over the last decade, the composition of the gut microbiota has been found to correlate with the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points to the various...
5.
Das T, Hang H
Viruses
. 2023 Dec;
15(12).
PMID: 38140570
Interferon-induced transmembrane proteins (IFITM1, 2 and 3) are important host antiviral defense factors. They are active against viruses like the influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV),...
6.
Tsukidate T, Hespen C, Hang H
RSC Chem Biol
. 2023 Nov;
4(12):1014-1036.
PMID: 38033733
Pattern recognition receptors (PRRs) represent a re-emerging class of therapeutic targets for vaccine adjuvants, inflammatory diseases and cancer. In this review article, we summarize exciting developments in discovery and characterization...
7.
Klupt S, Fam K, Zhang X, Chodisetti P, Mehmood A, Boyd T, et al.
bioRxiv
. 2023 Nov;
PMID: 38014356
is a microbiota species in humans that can modulate host immunity, but has also acquired antibiotic resistance and is a major cause of hospital-associated infections. Notably, diverse strains of produce...
8.
Jang K, Heaney T, London M, Ding Y, Putzel G, Yeung F, et al.
Cell Host Microbe
. 2023 Aug;
31(9):1450-1468.e8.
PMID: 37652008
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing...
9.
Zhao X, Stein K, Chen V, Griffin M, Lairson L, Hang H
Nat Chem Biol
. 2023 May;
19(10):1205-1214.
PMID: 37248411
The microbiota generates diverse metabolites to modulate host physiology and disease, but their protein targets and mechanisms of action have not been fully elucidated. To address this challenge, we explored...
10.
Griffin M, Tsukidate T, Hang H
ACS Chem Biol
. 2023 May;
18(6):1368-1377.
PMID: 37172210
The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies on species revealed peptidoglycan remodeling and activation...