Markus Grammel
Overview
Explore the profile of Markus Grammel including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
346
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Recent Articles
1.
Zimmer F, Quest B, Grammel M
Biotechnol Law Rep
. 2014 Nov;
33(5):171-180.
PMID: 25371598
No abstract available.
2.
Yu X, Woolery A, Luong P, Hao Y, Grammel M, Westcott N, et al.
Mol Cell Proteomics
. 2014 Jul;
13(11):3164-76.
PMID: 25073739
AMPylation (adenylylation) is a recently discovered mechanism employed by infectious bacteria to regulate host cell signaling. However, despite significant effort, only a few host targets have been identified, limiting our...
3.
Grammel M, Hang H
Nat Chem Biol
. 2013 Jul;
9(8):475-84.
PMID: 23868317
Functional tools are needed to understand complex biological systems. Here we review how chemical reporters in conjunction with bioorthogonal labeling methods can be used to image and retrieve nucleic acids,...
4.
Grammel M, Hang H
Methods Mol Biol
. 2013 Feb;
981:201-10.
PMID: 23381864
Bioorthogonal chemical proteomics is a valuable method to identify enzyme-specific substrates, a challenging task by traditional biochemical standards. The addition of recombinant enzyme and alkynyl chemical reporter to complex protein...
5.
Grammel M, Hang H, Conrad N
Chembiochem
. 2012 Apr;
13(8):1112-5.
PMID: 22513998
A versatile "clickable" nucleoside: Metabolic labeling of cells is useful in studying the dynamics of biological molecules. N(6) pA can be utilized by all three mammalian RNA polymerases, as well...
6.
Grammel M, Dossa P, Taylor-Salmon E, Hang H
Chem Commun (Camb)
. 2011 Nov;
48(10):1473-4.
PMID: 22080199
Orthogonal amino acid reporters allow the selective labeling of different cell types in heterogeneous populations through the expression of engineered aminoacyl tRNA synthetases. Here, we demonstrate that para-ethynylphenylalanine (PEP) can...
7.
Grammel M, Luong P, Orth K, Hang H
J Am Chem Soc
. 2011 Sep;
133(43):17103-5.
PMID: 21942216
Protein AMPylation is an emerging post-translational modification, which plays key roles in bacterial pathogenesis and cell biology. Enzymes with AMPylation activity, referred to as AMPylators, have been identified in several...
8.
Yang Y, Yu-Ying Y, Grammel M, Markus G, Hang H, Howard H
Bioorg Med Chem Lett
. 2011 Jun;
21(17):4976-9.
PMID: 21669532
Proteomic studies have identified a plethora of lysine acetylated proteins in eukaryotes and bacteria. Determining the individual lysine acetyltransferases responsible for each protein acetylation mark is crucial for elucidating the...
9.
Yang Y, Grammel M, Raghavan A, Charron G, Hang H
Chem Biol
. 2010 Nov;
17(11):1212-22.
PMID: 21095571
The advances in bioorthogonal ligation methods have provided new opportunities for proteomic analysis of newly synthesized proteins, posttranslational modifications, and specific enzyme families using azide/alkyne-functionalized chemical reporters and activity-based probes....
10.
Breitkopf S, Oppermann F, Keri G, Grammel M, Daub H
J Proteome Res
. 2010 Sep;
9(11):6033-43.
PMID: 20866107
Inhibition of deregulated protein kinases by small molecule drugs has evolved into a major therapeutic strategy for the treatment of human malignancies. Knowledge about direct cellular targets of kinase-selective drugs...