Howard C Hang
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Explore the profile of Howard C Hang including associated specialties, affiliations and a list of published articles.
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123
Citations
4600
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Recent Articles
11.
Peng T, Das T, Ding K, Hang H
Protein Sci
. 2023 Mar;
32(4):e4618.
PMID: 36883310
Post-translational modifications (PTMs) of proteins not only exponentially increase the diversity of proteoforms, but also contribute to dynamically modulating the localization, stability, activity, and interaction of proteins. Understanding the biological...
12.
Jang K, Heaney T, London M, Ding Y, Yeung F, Ercelen D, et al.
bioRxiv
. 2023 Feb;
PMID: 36778381
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing...
13.
Griffin M, Tsukidate T, Hang H
bioRxiv
. 2023 Feb;
PMID: 36747725
The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies on species revealed peptidoglycan remodeling and activation...
14.
Yang X, Zhao X, Chen V, Hang H
RSC Chem Biol
. 2022 Dec;
3(12):1397-1402.
PMID: 36544573
Bile acids are important gut microbiota metabolites that regulate both host and microbial functions. To identify the direct protein targets of bile acids in , we synthesized and validated the...
15.
Griffin M, Klupt S, Espinosa J, Hang H
Cell Chem Biol
. 2022 Nov;
30(5):436-456.
PMID: 36417916
The bacterial cell wall is composed of a highly crosslinked matrix of glycopeptide polymers known as peptidoglycan that dictates bacterial cell morphology and protects against environmental stresses. Regulation of peptidoglycan...
16.
Forster E, Yang X, Tai A, Hang H, Shen A
ACS Chem Biol
. 2022 Oct;
17(11):3086-3099.
PMID: 36279369
is a Gram-positive anaerobic bacterium that is the leading cause of hospital-acquired gastroenteritis in the US. In the gut milieu, encounters microbiota-derived, growth-inhibiting bile acids that are thought to be...
17.
Yang X, Stein K, Hang H
Nat Chem Biol
. 2022 Sep;
19(1):91-100.
PMID: 36175659
Bile acids are prominent host and microbiota metabolites that modulate host immunity and microbial pathogenesis. However, the mechanisms by which bile acids suppress microbial virulence are not clear. To identify...
18.
Das T, Yang X, Lee H, Garst E, Valencia E, Chandran K, et al.
ACS Chem Biol
. 2022 Jul;
17(8):2109-2120.
PMID: 35861660
Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral proteins that are active against many viruses, including influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus...
19.
Griffin M, Hang H
Neoplasia
. 2022 Jul;
31:100818.
PMID: 35816968
The human microbiota acts as a diverse source of molecular cues that influence the development and homeostasis of the immune system. Beyond endogenous roles in the human holobiont, host-microbial interactions...
20.
Hespen C, Zhao X, Hang H
Chem Commun (Camb)
. 2022 May;
58(46):6598-6601.
PMID: 35584401
To further understand the mechanisms of muramyl dipeptide (MDP) sensing by NOD2, we evaluated key properties involved in the formation of the Arf6-MDP-NOD2 complex in mammalian cells. We found that...