Matthew E Griffin
Overview
Explore the profile of Matthew E Griffin including associated specialties, affiliations and a list of published articles.
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25
Citations
451
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Recent Articles
1.
Falco N, Griffin M
Curr Opin Chem Biol
. 2024 Nov;
84:102551.
PMID: 39615426
Our microbiota plays crucial roles in immune development and homeostasis and has been implicated in virtually all major diseases of the 21st century. Nevertheless, our understanding of the exact microbial...
2.
Jang K, Heaney T, London M, Ding Y, Putzel G, Yeung F, et al.
Cell Host Microbe
. 2023 Aug;
31(9):1450-1468.e8.
PMID: 37652008
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing...
3.
Griffin M, Thompson J, Xiao Y, Sweredoski M, Aksenfeld R, Jensen E, et al.
bioRxiv
. 2023 Jul;
PMID: 37398272
The post-translational modification (PTM) of proteins by O-linked β--acetyl-D-glucosamine (O-GlcNAcylation) is widespread across the proteome during the lifespan of all multicellular organisms. However, nearly all functional studies have focused on...
4.
Zhao X, Stein K, Chen V, Griffin M, Lairson L, Hang H
Nat Chem Biol
. 2023 May;
19(10):1205-1214.
PMID: 37248411
The microbiota generates diverse metabolites to modulate host physiology and disease, but their protein targets and mechanisms of action have not been fully elucidated. To address this challenge, we explored...
5.
Griffin M, Tsukidate T, Hang H
ACS Chem Biol
. 2023 May;
18(6):1368-1377.
PMID: 37172210
The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies on species revealed peptidoglycan remodeling and activation...
6.
Jang K, Heaney T, London M, Ding Y, Yeung F, Ercelen D, et al.
bioRxiv
. 2023 Feb;
PMID: 36778381
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing...
7.
Griffin M, Tsukidate T, Hang H
bioRxiv
. 2023 Feb;
PMID: 36747725
The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies on species revealed peptidoglycan remodeling and activation...
8.
Griffin M, Klupt S, Espinosa J, Hang H
Cell Chem Biol
. 2022 Nov;
30(5):436-456.
PMID: 36417916
The bacterial cell wall is composed of a highly crosslinked matrix of glycopeptide polymers known as peptidoglycan that dictates bacterial cell morphology and protects against environmental stresses. Regulation of peptidoglycan...
9.
Griffin M, Hang H
Neoplasia
. 2022 Jul;
31:100818.
PMID: 35816968
The human microbiota acts as a diverse source of molecular cues that influence the development and homeostasis of the immune system. Beyond endogenous roles in the human holobiont, host-microbial interactions...
10.
Griffin M, Hsieh-Wilson L
Cell
. 2022 Jul;
185(15):2657-2677.
PMID: 35809571
Cellular carbohydrates or glycans are critical mediators of biological function. Their remarkably diverse structures and varied activities present exciting opportunities for understanding many areas of biology. In this primer, we...