Holger B Kramer
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Explore the profile of Holger B Kramer including associated specialties, affiliations and a list of published articles.
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43
Citations
1650
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Recent Articles
21.
Scotti J, Leung I, Ge W, Bentley M, Paps J, Kramer H, et al.
Proc Natl Acad Sci U S A
. 2014 Sep;
111(37):13331-6.
PMID: 25197067
The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabilization, hypoxia sensing, and translational regulation. The hypoxia-inducible factor (HIF) sensing system is conserved in animals, but not in other...
22.
Merkestein M, McTaggart J, Lee S, Kramer H, McMurray F, Lafond M, et al.
PLoS One
. 2014 May;
9(5):e97162.
PMID: 24842286
Single nucleotide polymorphisms in the first intron of the fat-mass-and-obesity-related gene FTO are associated with increased body weight and adiposity. Increased expression of FTO is likely underlying this obesity phenotype,...
23.
McGouran J, Gaertner S, Altun M, Kramer H, Kessler B
Chem Biol
. 2013 Dec;
20(12):1447-55.
PMID: 24290882
Posttranslational modification with ubiquitin (Ub) controls many cellular processes, and aberrant ubiquitination can contribute to cancer, immunopathology, and neurodegeneration. The versatility arises from the ability of Ub to form polymer...
24.
Fye H, Wright-Drakesmith C, Kramer H, Camey S, da Costa A, Jeng A, et al.
PLoS One
. 2013 Aug;
8(7):e68381.
PMID: 23935864
Background: Hepatocellular Carcinoma is the third most common cause of cancer related death worldwide, often diagnosed by measuring serum AFP; a poor performance stand-alone biomarker. With the aim of improving...
25.
Frleta D, Ochoa C, Kramer H, Khan S, Stacey A, Borrow P, et al.
J Clin Invest
. 2012 Nov;
122(12):4685-97.
PMID: 23160198
Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1,...
26.
Kramer H, Nicholson B, Kessler B, Altun M
Biochim Biophys Acta
. 2012 May;
1823(11):2029-37.
PMID: 22613766
Background: Synthetic probes that mimic natural substrates can enable the detection of enzymatic activities in a cellular environment. One area where such activity-based probes have been applied is the ubiquitin-proteasome...
27.
McGouran J, Kramer H, Mackeen M, Di Gleria K, Altun M, Kessler B
Org Biomol Chem
. 2012 Mar;
10(17):3379-83.
PMID: 22453277
Novel ubiquitin-based active site probes including a fluorescent tag have been developed and evaluated. A new, functionalizable electrophilic trap is utilized allowing for late stage diversification of the probe. Attachment...
28.
Altun M, Kramer H, Willems L, McDermott J, Leach C, Goldenberg S, et al.
Chem Biol
. 2011 Nov;
18(11):1401-12.
PMID: 22118674
Converting lead compounds into drug candidates is a crucial step in drug development, requiring early assessment of potency, selectivity, and off-target effects. We have utilized activity-based chemical proteomics to determine...
29.
Ternette N, Wright C, Kramer H, Altun M, Kessler B
Virol J
. 2011 Sep;
8(1):442.
PMID: 21933386
ABSTRACT: A large quantitative study was carried out to compare the proteome of respiratory syncytial virus (RSV) infected versus uninfected cells in order to determine novel pathways regulated during viral...
30.
Chowdhury R, Flashman E, Mecinovic J, Kramer H, Kessler B, Frapart Y, et al.
J Mol Biol
. 2011 May;
410(2):268-79.
PMID: 21601578
The hypoxic response in animals is mediated via the transcription factor hypoxia-inducible factor (HIF). An oxygen-sensing component of the HIF system is provided by Fe(II) and 2-oxoglutarate-dependent oxygenases that catalyse...