Michael A McDonough
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Explore the profile of Michael A McDonough including associated specialties, affiliations and a list of published articles.
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117
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5255
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Recent Articles
1.
Li Z, Wu Y, Zhen S, Su K, Zhang L, Yang F, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
134(45):e202211510.
PMID: 38505687
Target-directed dynamic combinatorial chemistry has emerged as a useful tool for hit identification, but has not been widely used, in part due to challenges associated with analyses involving complex mixtures....
2.
Brasnett A, Pfeffer I, Brewitz L, Chowdhury R, Nakashima Y, Tumber A, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(26):14778-14784.
PMID: 38505373
Aspartate/asparagine-β-hydroxylase (AspH) is a human 2-oxoglutarate (2OG) and Fe oxygenase that catalyses C3 hydroxylations of aspartate/asparagine residues of epidermal growth factor-like domains (EGFDs). Unusually, AspH employs two histidine residues to...
3.
Thomas A, Serafini M, Grant E, Coombs E, Bluck J, Schiedel M, et al.
ACS Chem Biol
. 2023 Oct;
18(11):2405-2417.
PMID: 37874862
Target validation remains a challenge in drug discovery, which leads to a high attrition rate in the drug discovery process, particularly in Phase II clinical trials. Consequently, new approaches to...
4.
Figg Jr W, Fiorini G, Chowdhury R, Nakashima Y, Tumber A, McDonough M, et al.
Proteins
. 2023 Jul;
91(11):1510-1524.
PMID: 37449559
The hypoxia-inducible factor (HIF) prolyl-hydroxylases (human PHD1-3) catalyze prolyl hydroxylation in oxygen-dependent degradation (ODD) domains of HIFα isoforms, modifications that signal for HIFα proteasomal degradation in an oxygen-dependent manner. PHD...
5.
Miura T, Malla T, Owen C, Tumber A, Brewitz L, McDonough M, et al.
Nat Chem
. 2023 May;
15(7):998-1005.
PMID: 37217786
γ-Amino acids can play important roles in the biological activities of natural products; however, the ribosomal incorporation of γ-amino acids into peptides is challenging. Here we report how a selection...
6.
Choi H, Hardy A, Leissing T, Chowdhury R, Nakashima Y, Ge W, et al.
Commun Chem
. 2023 Jan;
3(1):52.
PMID: 36703414
Factor inhibiting hypoxia-inducible factor (FIH) is a 2-oxoglutarate-dependent protein hydroxylase that catalyses C3 hydroxylations of protein residues. We report FIH can accept (D)- and (L)-residues for hydroxylation. The substrate selectivity...
7.
Li Z, Wu Y, Zhen S, Su K, Zhang L, Yang F, et al.
Angew Chem Int Ed Engl
. 2022 Sep;
61(45):e202211510.
PMID: 36112310
Target-directed dynamic combinatorial chemistry has emerged as a useful tool for hit identification, but has not been widely used, in part due to challenges associated with analyses involving complex mixtures....
8.
Baker Y, Thorpe C, Chen J, Poller L, Cox L, Kumar P, et al.
Nat Commun
. 2022 Jul;
13(1):4036.
PMID: 35821218
Oligonucleotides that target mRNA have great promise as therapeutic agents for life-threatening conditions but suffer from poor bioavailability, hence high cost. As currently untreatable diseases come within the reach of...
9.
Kaur S, Tam N, McDonough M, Schofield C, Aik W
Nucleic Acids Res
. 2022 Mar;
50(7):4148-4160.
PMID: 35333330
AlkB homologue 5 (ALKBH5) is a ferrous iron and 2-oxoglutarate dependent oxygenase that demethylates RNA N6-methyladenosine (m6A), a post-transcriptional RNA modification with an emerging set of regulatory roles. Along with...
10.
Lucic A, Malla T, Calvopina K, Tooke C, Brem J, McDonough M, et al.
Antibiotics (Basel)
. 2022 Mar;
11(3).
PMID: 35326858
Carbapenems are important antibacterials and are both substrates and inhibitors of some β-lactamases. We report studies on the reaction of the unusual carbapenem biapenem, with the subclass B1 metallo-β-lactamases VIM-1...