Benedikt M Kessler
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Explore the profile of Benedikt M Kessler including associated specialties, affiliations and a list of published articles.
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286
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12326
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Recent Articles
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2.
Li H, Pike A, Chang Y, Prakaash D, Gelova Z, Stanka J, et al.
Nat Commun
. 2025 Jan;
16(1):721.
PMID: 39820269
Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects....
3.
Wijnhoven P, Konietzny R, Blackford A, Travers J, Kessler B, Nishi R, et al.
Mol Cell
. 2025 Jan;
85(3):665.
PMID: 39818214
No abstract available.
4.
OBrien D, Jones H, Shi Y, Guenther F, Vendrell I, Viner R, et al.
J Proteome Res
. 2025 Jan;
24(2):479-490.
PMID: 39804742
Inhibition of the mitochondrial deubiquitinating (DUB) enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson's disease and mitophagy-related disorders. We integrated structural and quantitative proteomics...
5.
Liang Z, Damianou A, Grigoriou A, Jones H, Sharlandijeva V, Lassen F, et al.
STAR Protoc
. 2024 Oct;
5(4):103417.
PMID: 39460941
The NLRP3 inflammasome is a key multi-protein complex controlling inflammation, particularly interleukin-1β (IL-1β) production. Here, we present a protocol to profile spatially resolved NLRP3 inflammasome complexes using ascorbic peroxidase 2...
6.
Zhu K, Chatrin C, Suskiewicz M, Aucagne V, Foster B, Kessler B, et al.
EMBO Rep
. 2024 Sep;
25(10):4172-4189.
PMID: 39242775
The recent discovery of non-proteinaceous ubiquitylation substrates broadened our understanding of this modification beyond conventional protein targets. However, the existence of additional types of substrates remains elusive. Here, we present...
7.
Yang H, Fouad S, Smith P, Bae E, Ji Y, Lan X, et al.
Sci Adv
. 2024 Aug;
10(32):eado0636.
PMID: 39121215
Ubiquitination is a crucial posttranslational modification required for the proper repair of DNA double-strand breaks (DSBs) induced by ionizing radiation (IR). DSBs are mainly repaired through homologous recombination (HR) when...
8.
Lassen F, Venkatesh S, Baya N, Hill B, Zhou W, Bloemendal A, et al.
Cell Genom
. 2024 Jun;
4(7):100602.
PMID: 38944039
The phenotypic impact of compound heterozygous (CH) variation has not been investigated at the population scale. We phased rare variants (MAF ∼0.001%) in the UK Biobank (UKBB) exome-sequencing data to...
9.
Stieger A, Huber M, Yu Z, Kessler B, Fischer R, Andereggen L, et al.
Metabolites
. 2024 Jun;
14(6).
PMID: 38921469
Indoleamine 2,3-deoxygenase (IDO) plays an important role in the catabolism of the amino acid tryptophan. Tryptophan and its metabolites are key immune modulators. Increased IDO activity has been observed in...
10.
Manolis D, Hasan S, Maraveyas A, OBrien D, Kessler B, Kramer H, et al.
J Biol Chem
. 2024 May;
300(6):107399.
PMID: 38777147
The G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) mediates essential functions in several cell types and is implicated in cardiovascular pathologies, skin diseases, migraine, and cancer. To date, the...