Holger B Kramer
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Explore the profile of Holger B Kramer including associated specialties, affiliations and a list of published articles.
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43
Citations
1650
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Recent Articles
11.
Glycomimetic affinity-enrichment proteomics identifies partners for a clinically-utilized iminosugar
Cruz I, Barry C, Kramer H, Chuang C, Lloyd S, van der Spoel A, et al.
Chem Sci
. 2019 Apr;
4(9):3442-3446.
PMID: 31031905
Widescale evaluation of interacting partners for carbohydrates is an underexploited area. Probing of the 'glyco-interactome' has particular relevance given the lack of direct genetic control of glycoconjugate biosynthesis. Here we...
12.
Lahmann C, Kramer H, Ashcroft F
PLoS One
. 2019 Apr;
14(4):e0215989.
PMID: 30998784
[This corrects the article DOI: 10.1371/journal.pone.0134476.].
13.
Cruz I, Coley H, Kramer H, Madhuri T, Safuwan N, Angelino A, et al.
Cancer Genomics Proteomics
. 2016 Dec;
14(1):35-51.
PMID: 28031236
Background: Carboplatin and paclitaxel form the cornerstone of chemotherapy for epithelial ovarian cancer, however, drug resistance to these agents continues to present challenges. Despite extensive research, the mechanisms underlying this...
14.
Behrens A, Vasiljevic S, Pritchard L, Harvey D, Andev R, Krumm S, et al.
Cell Rep
. 2016 Mar;
14(11):2695-706.
PMID: 26972002
The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that shield it from immune surveillance. The high density of glycans on the trimer surface imposes steric...
15.
Jallow S, Leligdowicz A, Kramer H, Onyango C, Cotten M, Wright C, et al.
Eur J Immunol
. 2015 Sep;
45(9):2701.
PMID: 26343564
No abstract available.
16.
Lahmann C, Kramer H, Ashcroft F
PLoS One
. 2015 Jul;
10(7):e0134476.
PMID: 26225433
Activating mutations in the Kir6.2 (KCNJ11) subunit of the ATP-sensitive potassium channel cause neonatal diabetes (ND). Patients with severe mutations also suffer from neurological complications. Glibenclamide blocks the open KATP...
17.
Tarhonskaya H, Hardy A, Howe E, Loik N, Kramer H, McCullagh J, et al.
J Biol Chem
. 2015 Jun;
290(32):19726-42.
PMID: 26112411
The hypoxia-inducible factor (HIF) hydroxylases regulate hypoxia sensing in animals. In humans, they comprise three prolyl hydroxylases (PHD1-3 or EGLN1-3) and factor inhibiting HIF (FIH). FIH is an asparaginyl hydroxylase...
18.
Jallow S, Leligdowicz A, Kramer H, Onyango C, Cotten M, Wright C, et al.
Eur J Immunol
. 2015 May;
45(8):2232-42.
PMID: 26018465
Both the recognition of HIV-infected cells and the immunogenicity of candidate CTL vaccines depend on the presentation of a peptide epitope at the cell surface, which in turn depends on...
19.
Pettingill P, Kramer H, Coebergh J, Pettingill R, Maxwell S, Nibber A, et al.
Neurology
. 2015 Feb;
84(12):1233-41.
PMID: 25636713
Objective: To search for antibodies against neuronal cell surface proteins. Methods: Using immunoprecipitation from neuronal cultures and tandem mass spectrometry, we identified antibodies against the α1 subunit of the γ-aminobutyric...
20.
Altun M, Walter T, Kramer H, Herr P, Iphofer A, Bostrom J, et al.
PLoS One
. 2015 Jan;
10(1):e0115344.
PMID: 25590432
Ovarian tumor domain containing proteases cleave ubiquitin (Ub) and ubiquitin-like polypeptides from proteins. Here we report the crystal structure of human otubain 2 (OTUB2) in complex with a ubiquitin-based covalent...