HIV-1 Infection-induced Apoptotic Microparticles Inhibit Human DCs Via CD44

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2012 Nov 20

PMID 23160198

Citations 34

Authors

Davor Frleta

Carolyn E Ochoa

Holger B Kramer

Shaukat Ali Khan

Andrea R Stacey

Persephone Borrow

Benedikt M Kessler

Barton F Haynes

Nina Bhardwaj

Affiliations

Soon will be listed here.

Abstract

Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from patients with HIV specifically inhibited DC function. This suppression was mediated by elevated apoptotic microparticles derived from dying cells during acute HIV-1 infection. Apoptotic microparticles bound to and inhibited DCs through the hyaluronate receptor CD44. These data suggest that targeting this CD44-mediated inhibition by apoptotic microparticles could be a novel strategy to potentiate DC activation of HIV-specific immunity.

Citing Articles

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