Gijsbert A van der Marel
Overview
Explore the profile of Gijsbert A van der Marel including associated specialties, affiliations and a list of published articles.
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239
Citations
2772
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Recent Articles
1.
Osterlid K, Sorieul C, Unione L, Li S, Garcia-Sepulveda C, Carboni F, et al.
J Am Chem Soc
. 2025 Jan;
147(3):2829-2840.
PMID: 39792791
is a Gram-positive bacterium that is responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the development of new treatment interventions, and...
2.
Artola M, Aerts J, van der Marel G, Rovira C, Codee J, Davies G, et al.
J Am Chem Soc
. 2024 Aug;
146(36):24729-24741.
PMID: 39213505
Activity-based protein profiling (ABPP) is an effective technology for the identification and functional annotation of enzymes in complex biological samples. ABP designs are normally directed to an enzyme active site...
3.
Ofman T, Heming J, Nin-Hill A, Kullmer F, Moran E, Bennett M, et al.
Chemistry
. 2024 Apr;
30(31):e202400723.
PMID: 38623783
Glycoside hydrolases (glycosidases) take part in myriad biological processes and are important therapeutic targets. Competitive and mechanism-based inhibitors are useful tools to dissect their biological role and comprise a good...
4.
Minnee H, Rack J, van der Marel G, Overkleeft H, Codee J, Ahel I, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
136(4):e202313317.
PMID: 38516349
The transfer of an adenosine diphosphate (ADP) ribose moiety to a nucleophilic side chain by consumption of nicotinamide adenine dinucleotide is referred to as ADP-ribosylation, which allows for the spatiotemporal...
5.
Engelsma S, Nardozza A, de Saint Aulaire P, Overkleeft H, van der Marel G, Ladurner A, et al.
Chembiochem
. 2024 Mar;
25(8):e202300865.
PMID: 38442082
Mono-ADP-ribosylation is a dynamic post-translational modification (PTM) with important roles in cell signalling. This modification occurs on a wide variety of amino acids, and one of the canonical modification sites...
6.
Remmerswaal W, Elferink H, Houthuijs K, Hansen T, Ter Braak F, Berden G, et al.
J Org Chem
. 2024 Jan;
89(3):1618-1625.
PMID: 38235652
Minimal structural differences in the structure of glycosyl donors can have a tremendous impact on their reactivity and the stereochemical outcome of their glycosylation reactions. Here, we used a combination...
7.
Males A, Kok K, Nin-Hill A, de Koster N, van den Beukel S, Beenakker T, et al.
Chem Sci
. 2023 Nov;
14(46):13581-13586.
PMID: 38033892
Class I inverting exo-acting α-1,2-mannosidases (CAZY family GH47) display an unusual catalytic itinerary featuring ring-flipped mannosides, → → . Conformationally locked compounds, such as kifunensine, display nanomolar inhibition but large...
8.
Minnee H, Rack J, van der Marel G, Overkleeft H, Codee J, Ahel I, et al.
Angew Chem Int Ed Engl
. 2023 Oct;
63(4):e202313317.
PMID: 37903139
The transfer of an adenosine diphosphate (ADP) ribose moiety to a nucleophilic side chain by consumption of nicotinamide adenine dinucleotide is referred to as ADP-ribosylation, which allows for the spatiotemporal...
9.
Kuo C, Su Q, van den Nieuwendijk A, Beenakker T, Offen W, Willems L, et al.
Org Biomol Chem
. 2023 Sep;
21(38):7813-7820.
PMID: 37724332
Acid β-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-β-galactosidases involved in lysosomal glycoconjugate metabolism. Deficiency of GLB1 may result in the lysosomal storage disorders GM1 gangliosidosis, Morquio B syndrome, and...
10.
van Gelder M, van der Zanden S, Vriends M, Wagensveld R, van der Marel G, Codee J, et al.
J Med Chem
. 2023 Aug;
66(16):11390-11398.
PMID: 37561481
The anthracycline anti-cancer drugs are intensely used in the clinic to treat a wide variety of cancers. They generate DNA double strand breaks, but recently the induction of chromatin damage...