Bogdan I Florea
Overview
Explore the profile of Bogdan I Florea including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
135
Citations
2346
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0
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Recent Articles
1.
McKenna S, Florea B, Zisterer D, van Kasteren S, McGouran J
RSC Chem Biol
. 2024 Aug;
5(8):776-786.
PMID: 39092446
Affinity-based probes are valuable tools for detecting binding interactions between small molecules and proteins in complex biological environments. Metalloproteins are a class of therapeutically significant biomolecules which bind metal ions...
2.
Paone P, Latousakis D, Terrasi R, Vertommen D, Jian C, Borlandelli V, et al.
Gut
. 2024 May;
73(10):1632-1649.
PMID: 38740509
Objective: To decipher the mechanisms by which the major human milk oligosaccharide (HMO), 2'-fucosyllactose (2'FL), can affect body weight and fat mass gain on high-fat diet (HFD) feeding in mice....
3.
Schaftenaar F, van Dam A, de Bruin G, Depuydt M, de Mol J, Amersfoort J, et al.
Arterioscler Thromb Vasc Biol
. 2024 Apr;
44(6):1346-1364.
PMID: 38660806
Background: Atherosclerosis is the major underlying pathology of cardiovascular disease and is driven by dyslipidemia and inflammation. Inhibition of the immunoproteasome, a proteasome variant that is predominantly expressed by immune...
4.
Trogisch F, Koser F, Michel S, Liem D, Florea B, Hecker M, et al.
Front Mol Biosci
. 2024 Mar;
11:1148948.
PMID: 38516190
Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure. Previously, we have...
5.
Sachs W, Blume L, Loreth D, Schebsdat L, Hatje F, Koehler S, et al.
Nat Commun
. 2024 Mar;
15(1):1897.
PMID: 38429282
Kidney filtration is ensured by the interaction of podocytes, endothelial and mesangial cells. Immunoglobulin accumulation at the filtration barrier is pathognomonic for glomerular injury. The mechanisms that regulate filter permeability...
6.
Jiang M, Huizenga M, Wirt J, Paloczi J, Amedi A, van den Berg R, et al.
Nat Commun
. 2023 Dec;
14(1):8039.
PMID: 38052772
Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated side effects. Here, we report...
7.
Kuo C, Su Q, van den Nieuwendijk A, Beenakker T, Offen W, Willems L, et al.
Org Biomol Chem
. 2023 Sep;
21(38):7813-7820.
PMID: 37724332
Acid β-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-β-galactosidases involved in lysosomal glycoconjugate metabolism. Deficiency of GLB1 may result in the lysosomal storage disorders GM1 gangliosidosis, Morquio B syndrome, and...
8.
Reichelt J, Sachs W, Frombling S, Fehlert J, Studencka-Turski M, Betz A, et al.
Nat Commun
. 2023 Apr;
14(1):2453.
PMID: 37117182
No abstract available.
9.
Reichelt J, Sachs W, Frombling S, Fehlert J, Studencka-Turski M, Betz A, et al.
Nat Commun
. 2023 Apr;
14(1):2114.
PMID: 37055432
Little is known about the mechanistic significance of the ubiquitin proteasome system (UPS) in a kidney autoimmune environment. In membranous nephropathy (MN), autoantibodies target podocytes of the glomerular filter resulting...
10.
van Leeuwen T, Doelman W, van den Kieboom R, Florea B, van Kasteren S
Chembiochem
. 2023 Mar;
24(8):e202300082.
PMID: 36881517
Uptake and processing of antigens by antigen presenting cells (APCs) is a key step in the initiation of the adaptive immune response. Studying these processes is complex as the identification...