Dmitri V Filippov
Overview
Explore the profile of Dmitri V Filippov including associated specialties, affiliations and a list of published articles.
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140
Citations
2579
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Recent Articles
1.
Uribe I, Zahn E, Searfoss R, Kim H, Dasovich M, Voorneveld J, et al.
J Proteome Res
. 2025 Mar;
PMID: 40079415
ADP-ribosylation, characterized by the addition of adenosine diphosphate ribose, can occur in both monomeric (MARylation) and polymeric (PARylation) forms. Little is known about the specific contributions of MARylation and PARylation...
2.
van der Heijden F, Weijers S, Bleijerveld O, Kliza K, Vermeulen M, Filippov D, et al.
Chembiochem
. 2025 Feb;
26(6):e202400882.
PMID: 39898787
Olaparib is a widely used PARP inhibitor for the treatment of BRCA-mutated cancers. To comprehensively understand the drug's clinical impact, measuring its interactions with intended on- and off-targets is crucial....
3.
Isendoorn M, Castello G, Koc C, Meeuwenoord N, Codee J, Ossendorp F, et al.
Chembiochem
. 2024 Oct;
25(23):e202400583.
PMID: 39381901
Ligands for Toll-like-receptor 2 (TLR2) have demonstrated significant potential as immune-stimulating components in synthetic vaccines. Activation of TLR2 relies on the formation of dimeric complexes with either TLR1 or TLR6...
4.
Rack J, Voorneveld J, Longarini E, Wijngaarden S, Zhu K, Peters A, et al.
J Biol Chem
. 2024 Sep;
300(11):107838.
PMID: 39342999
ADP-ribosylation is an ancient posttranslational modification with exceptional versatility in terms of breadth of modification targets including at least seven different amino acid side chains, various moieties on nucleic acids,...
5.
Ariza A, Liu Q, Cowieson N, Ahel I, Filippov D, Rack J
J Biol Chem
. 2024 Sep;
300(10):107770.
PMID: 39270823
Dynamic ADP-ribosylation signaling is a crucial pathway that controls fundamental cellular processes, in particular, the response to cellular stresses such as DNA damage, reactive oxygen species, and infection. In some...
6.
Noone D, Isendoorn M, Hamers S, Keizer M, Wulffele J, van der Velden T, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(37):e2404542121.
PMID: 39240968
Human C-reactive protein (CRP) is a pentameric complex involved in immune defense and regulation of autoimmunity. CRP is also a therapeutic target, with both administration and depletion of serum CRP...
7.
Minnee H, Codee J, Filippov D
Chembiochem
. 2024 Jul;
25(24):e202400440.
PMID: 38984757
Adenosine diphosphate (ADP)-ribosylation is a ubiquitous post-translational modification that regulates vital biological processes like histone reorganization and DNA-damage repair through the modification of various amino acid residues. Due to advances...
8.
Rijpkema K, Schuller M, van der Veer M, Rieken S, Chang D, Balic P, et al.
Org Lett
. 2024 Jun;
26(27):5700-5704.
PMID: 38935522
Protein adenosine diphosphate (ADP)-ribosylation is crucial for a proper immune response. Accordingly, viruses have evolved ADP-ribosyl hydrolases to remove these modifications, a prominent example being the SARS-CoV-2 NSP3 macrodomain, "Mac1"....
9.
Minnee H, Rack J, van der Marel G, Overkleeft H, Codee J, Ahel I, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
136(4):e202313317.
PMID: 38516349
The transfer of an adenosine diphosphate (ADP) ribose moiety to a nucleophilic side chain by consumption of nicotinamide adenine dinucleotide is referred to as ADP-ribosylation, which allows for the spatiotemporal...
10.
Zhang Z, Fu J, Rack J, Li C, Voorneveld J, Filippov D, et al.
Nat Commun
. 2024 Mar;
15(1):2452.
PMID: 38503748
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category. The pathogen Legionella pneumophila...