Harichandra D Tagad
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Explore the profile of Harichandra D Tagad including associated specialties, affiliations and a list of published articles.
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19
Citations
123
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Recent Articles
1.
Brown K, Robello M, Perciaccante A, Dinan J, Maity T, Lyons G, et al.
ACS Pharmacol Transl Sci
. 2024 Nov;
7(11):3559-3572.
PMID: 39539265
is commonly mutated in cancer, giving rise to loss of wild-type tumor suppressor function and increases in gain-of-function oncogenic roles. Thus, inhibition of mutant p53 and reactivation of wild-type function...
2.
Tagad H, Marin A, Hlushko R, Andrianov A
Biomacromolecules
. 2024 Sep;
25(10):6791-6800.
PMID: 39315416
Zwitterionic polymers, ampholytic macromolecules containing ionic moieties of opposite sign on the same pendant groups, exhibit strong protein-repulsive properties and an inherent biological inertness. For that reason, these highly hydrated...
3.
Lueckheide M, Marin A, Tagad H, Posey N, Prabhu V, Andrianov A
ACS Polym Au
. 2023 Oct;
3(5):354-364.
PMID: 37841951
Polyphosphazenes represent a class of intrinsically flexible polyelectrolytes with potent immunoadjuvant activity, which is enabled through non-covalent self-assembly with antigenic proteins by charge complexation. The formation of supramolecular complexes between...
4.
Tagad H, Marin A, Wang R, Yunus A, Fuerst T, Andrianov A
Molecules
. 2023 May;
28(10).
PMID: 37241958
The inclusion of fluorine motifs in drugs and drug delivery systems is an established tool for modulating their biological potency. Fluorination can improve drug specificity or boost the vehicle's ability...
5.
Tagad H, Brito J, Marin A, Buckley C, Wang H, Sun J, et al.
Biomacromolecules
. 2023 Apr;
24(5):2278-2290.
PMID: 37071718
Advanced multifunctional biomaterials are increasingly relying on clinically dictated patterns of selectivity against various biological targets. Integration of these frequently conflicting features into a single material surface may be best...
6.
Clausse V, Fang Y, Tao D, Tagad H, Sun H, Wang Y, et al.
ACS Pharmacol Transl Sci
. 2022 Oct;
5(10):993-1006.
PMID: 36268125
Wild-type P53-induced phosphatase 1 (WIP1), also known as or PP2Cδ, is a serine/threonine protein phosphatase induced by P53 after genotoxic stress. WIP1 inhibition has been proposed as a therapeutic strategy...
7.
Robello M, Zheng H, Saha M, George Rosenker K, Debnath S, Kumar J, et al.
Eur J Med Chem
. 2022 Sep;
243:114763.
PMID: 36179402
The wild-type p53 induced phosphatase 1 (Wip1), a member of the serine/threonine-specific PP2C family, is overexpressed in numerous human cancers. Wip1 dephosphorylates p53 as well as several kinases (such as...
8.
Clausse V, Tao D, Debnath S, Fang Y, Tagad H, Wang Y, et al.
J Biol Chem
. 2019 Sep;
294(46):17654-17668.
PMID: 31481464
WT P53-Induced Phosphatase 1 (WIP1) is a member of the magnesium-dependent serine/threonine protein phosphatase (PPM) family and is induced by P53 in response to DNA damage. In several human cancers,...
9.
Manna A, Zhao H, Wada J, Balagopalan L, Tagad H, Appella E, et al.
Proc Natl Acad Sci U S A
. 2018 Dec;
115(51):E11914-E11923.
PMID: 30510001
The T cell antigen receptor encounters foreign antigen during the immune response. Receptor engagement leads to activation of specific protein tyrosine kinases, which then phosphorylate multiple enzymes and adapter proteins....
10.
Debnath S, Kosek D, Tagad H, Durell S, Appella D, Acevedo R, et al.
J Biol Chem
. 2018 Apr;
293(21):7993-8008.
PMID: 29602904
Metal-dependent protein phosphatases (PPM) are evolutionarily unrelated to other serine/threonine protein phosphatases and are characterized by their requirement for supplementation with millimolar concentrations of Mg or Mn ions for activity...