Daniel H Appella
Overview
Explore the profile of Daniel H Appella including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
79
Citations
701
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Brown K, Robello M, Perciaccante A, Dinan J, Maity T, Lyons G, et al.
ACS Pharmacol Transl Sci
. 2024 Nov;
7(11):3559-3572.
PMID: 39539265
is commonly mutated in cancer, giving rise to loss of wild-type tumor suppressor function and increases in gain-of-function oncogenic roles. Thus, inhibition of mutant p53 and reactivation of wild-type function...
2.
Crystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain
Kumar J, Kosek D, Durell S, Miller Jenkins L, Debnath S, Coussens N, et al.
J Biol Chem
. 2024 Jul;
300(8):107561.
PMID: 39002674
Protein phosphatase 1D (PPM1D, Wip1) is induced by the tumor suppressor p53 during DNA damage response signaling and acts as an oncoprotein in several human cancers. Although PPM1D is a...
3.
Mannully S, Mahajna R, Nazzal H, Maree S, Zheng H, Appella D, et al.
Biomolecules
. 2024 Jun;
14(6).
PMID: 38927013
Ovarian cancer (OC) is one of the most lethal gynecologic cancers that is typically diagnosed at the very late stage of disease progression. Thus, there is an unmet need to...
4.
Tepper O, Appella D, Zheng H, Dzikowski R, Yavin E
ACS Sens
. 2024 Mar;
9(3):1458-1464.
PMID: 38446423
The evolution of drug resistance to many antimalarial drugs in the lethal strain of malaria () has been a great concern over the past 50 years. Among these drugs, artemisinin...
5.
Robello M, Nikolayevskiy H, Scerba M, Nahui Palomino R, Mercurio V, Appella D
ACS Pharmacol Transl Sci
. 2024 Jan;
7(1):259-273.
PMID: 38250006
Sulfanylbenzamide thioesters are molecules with anti-HIV activity that disrupt zinc coordination in the viral protein NCp7. These molecules are useful as topical microbicides; however, they are too unstable to be...
6.
Tepper O, Zheng H, Appella D, Yavin E
Chem Commun (Camb)
. 2023 Sep;
59(77):11593.
PMID: 37711096
Correction for 'Cyclopentane FIT-PNAs: bright RNA sensors' by Odelia Tepper , , 2021, , 540-543, https://doi.org/10.1039/D0CC07400D.
7.
Zheng H, Clausse V, Amarasekara H, Mazur S, Botos I, Appella D
JACS Au
. 2023 Jul;
3(7):1952-1964.
PMID: 37502163
Selective incorporation of conformational constraints into thyclotides can be used to modulate their binding to complementary oligonucleotides, increase polarity, and optimize uptake into HCT116 cells without assistance from moieties known...
8.
Rahman M, Bissa M, Silva de Castro I, Hait S, Stamos J, Bhuyan F, et al.
Nat Microbiol
. 2023 May;
8(8):1600.
PMID: 37217721
No abstract available.
9.
Rahman M, Bissa M, Silva de Castro I, Hait S, Stamos J, Bhuyan F, et al.
Nat Microbiol
. 2023 Apr;
8(5):905-918.
PMID: 37024617
The human immunodeficiency virus epidemic continues in sub-Saharan Africa, and particularly affects adolescent girls and women who have limited access to antiretroviral therapy. Here we report that the risk of...
10.
Clausse V, Fang Y, Tao D, Tagad H, Sun H, Wang Y, et al.
ACS Pharmacol Transl Sci
. 2022 Oct;
5(10):993-1006.
PMID: 36268125
Wild-type P53-induced phosphatase 1 (WIP1), also known as or PP2Cδ, is a serine/threonine protein phosphatase induced by P53 after genotoxic stress. WIP1 inhibition has been proposed as a therapeutic strategy...