Harichandra D Tagad
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Explore the profile of Harichandra D Tagad including associated specialties, affiliations and a list of published articles.
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19
Citations
123
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Recent Articles
11.
Tagad H, Debnath S, Clausse V, Saha M, Mazur S, Appella E, et al.
ChemMedChem
. 2018 Feb;
13(9):894-901.
PMID: 29476592
The wild-type p53 induced phosphatase 1, Wip1 (PP2Cδ), is a protein phosphatase 2C (PP2C) family serine/threonine phosphatase that negatively regulates the function of the tumor suppressor p53 and several of...
12.
Giardino Torchia M, Dutta D, Mittelstadt P, Guha J, Gaida M, Fish K, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(9):2174-2179.
PMID: 29440413
ZAP-70 is a tyrosine kinase that is essential for initiation of T cell antigen receptor (TCR) signaling. We have found that T cell p38 MAP kinase (MAPK), which is directly...
13.
Alam M, Gaida M, Debnath S, Tagad H, Miller Jenkins L, Appella E, et al.
PLoS Biol
. 2018 Jan;
16(1):e2004111.
PMID: 29357353
Nuclear factor of activated T cells (NFAT) transcription factors are required for induction of T-cell cytokine production and effector function. Although it is known that activation via the T-cell antigen...
14.
Miller Jenkins L, Feng H, Durell S, Tagad H, Mazur S, Tropea J, et al.
Biochemistry
. 2015 Mar;
54(11):2001-10.
PMID: 25753752
The p53 tumor suppressor is a critical mediator of the cellular response to stress. The N-terminal transactivation domain of p53 makes protein interactions that promote its function as a transcription...
15.
Tanoue K, Miller Jenkins L, Durell S, Debnath S, Sakai H, Tagad H, et al.
Biochemistry
. 2013 Aug;
52(34):5830-43.
PMID: 23906386
The PPM phosphatases require millimolar concentrations of Mg²⁺ or Mn²⁺ to activate phosphatase activity in vitro. The human phosphatases PP2Cα (PPM1A) and Wip1 (PPM1D) differ in their physiological function, substrate...
16.
Hamada Y, Tagad H, Nishimura Y, Ishiura S, Kiso Y
Bioorg Med Chem Lett
. 2011 Dec;
22(2):1130-5.
PMID: 22178553
Previously reported pentapeptidic BACE1 inhibitors, designed using a substrate-based approach, were used as lead compounds for the further design of non-peptidic BACE1 inhibitors. Although these peptidic and non-peptidic inhibitors, with...
17.
Tagad H, Hamada Y, Nguyen J, Hidaka K, Hamada T, Sohma Y, et al.
Bioorg Med Chem
. 2011 Aug;
19(17):5238-46.
PMID: 21803585
Previously, we reported potent pentapeptidic BACE1 inhibitors with the hydroxymethylcarbonyl isostere as a substrate transition-state mimic. To improve the in vitro potency, we further reported pentapeptidic inhibitors with carboxylic acid...
18.
Kakizawa T, Hidaka K, Hamada D, Yamaguchi R, Uemura T, Kitamura H, et al.
J Pept Sci
. 2010 May;
16(6):257-62.
PMID: 20474036
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is known to be involved in the production of amyloid beta-peptide in Alzheimer's disease and is a major target for current drug...
19.
Tagad H, Hamada Y, Nguyen J, Hamada T, Abdel-Rahman H, Yamani A, et al.
Bioorg Med Chem
. 2010 Apr;
18(9):3175-86.
PMID: 20381362
We previously reported potent BACE1 inhibitors KMI-420 and KMI-570 possessing a hydroxymethylcarbonyl isostere as a substrate transition-state mimic. Acidic moieties at the P(1)(') and P(4) positions of KMI inhibitors are...