Gentry N Patrick
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Explore the profile of Gentry N Patrick including associated specialties, affiliations and a list of published articles.
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27
Citations
1062
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Recent Articles
1.
Mei Y, Gosztyla M, Tan X, Dozier L, Wilkinson B, McKetney J, et al.
Cell Syst
. 2025 Mar;
:101204.
PMID: 40054464
The molecular composition of the excitatory synapse is incompletely defined due to its dynamic nature across developmental stages and neuronal populations. To address this gap, we apply proteomic mass spectrometry...
2.
Lawrence J, Aguilar-Calvo P, Ojeda-Juarez D, Khuu H, Soldau K, Pizzo D, et al.
J Neurosci
. 2023 Apr;
43(21):3970-3984.
PMID: 37019623
Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for...
3.
Hadidi K, Steinbuch K, Dozier L, Patrick G, Tor Y
Angew Chem Int Ed Engl
. 2023 Mar;
62(23):e202216784.
PMID: 36973168
Puromycin derivatives containing an emissive thieno[3,4-d]-pyrimidine core, modified with azetidine and 3,3-difluoroazetidine as Me N surrogates, exhibit translation inhibition and bactericidal activity similar to the natural antibiotic. The analogues are...
4.
Lorden G, Wozniak J, Dore K, Dozier L, Cates-Gatto C, Patrick G, et al.
Nat Commun
. 2022 Nov;
13(1):7200.
PMID: 36418293
Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are generally associated with cancer, gain-of-function variants in one isozyme, PKCα, are...
5.
Ojeda-Juarez D, Lawrence J, Soldau K, Pizzo D, Wheeler E, Aguilar-Calvo P, et al.
Neurobiol Dis
. 2022 Jul;
172:105834.
PMID: 35905927
Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion...
6.
Scudder S, Gonzales F, Howell K, Stein I, Dozier L, Anagnostaras S, et al.
eNeuro
. 2021 Mar;
8(3).
PMID: 33658307
Dynamic control of protein degradation via the ubiquitin proteasome system (UPS) is thought to play a crucial role in neuronal function and synaptic plasticity. The proteasome subunit Rpt6, an AAA...
7.
Kyriakakis P, Catanho M, Hoffner N, Thavarajah W, Hu V, Chao S, et al.
ACS Synth Biol
. 2018 Jan;
7(2):706-717.
PMID: 29301067
Transplanting metabolic reactions from one species into another has many uses as a research tool with applications ranging from optogenetics to crop production. Ferredoxin (Fd), the enzyme that most often...
8.
Gonzales F, Howell K, Dozier L, Anagnostaras S, Patrick G
Mol Cell Neurosci
. 2017 Dec;
88:62-69.
PMID: 29217409
Repeated exposure to cocaine produces structural and functional modifications at synapses from neurons in several brain regions including the nucleus accumbens. These changes are thought to underlie cocaine-induced sensitization. The...
9.
Tong W, Dwyer C, Thacker B, Glass C, Brown J, Hamill K, et al.
Mol Ther
. 2017 Sep;
25(12):2743-2752.
PMID: 28958576
Iduronidase (IDUA)-deficient mice accumulate glycosaminoglycans in cells and tissues and exhibit many of the same neuropathological symptoms of patients suffering from Mucopolysaccharidosis I. Intravenous enzyme-replacement therapy for Mucopolysaccharidosis I ameliorates...
10.
Marquez-Lona E, Torres-Machorro A, Gonzales F, Pillus L, Patrick G
PLoS One
. 2017 Jun;
12(6):e0179893.
PMID: 28662109
The ubiquitin proteasome system (UPS) is a highly conserved and tightly regulated biochemical pathway that degrades the majority of proteins in eukaryotic cells. Importantly, the UPS is responsible for counteracting...