Samantha L Scudder
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Explore the profile of Samantha L Scudder including associated specialties, affiliations and a list of published articles.
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9
Citations
191
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Recent Articles
1.
Szumlinski K, Herbert J, Mejia Espinoza B, Madory L, Scudder S
Addict Neurosci
. 2023 Jul;
7.
PMID: 37396410
Heavy drinking can induce early-onset dementia and increase the likelihood of the progression and severity of Alzheimer's Disease and related dementias (). Recently, we showed that alcohol-drinking by mature adult...
2.
Baimel C, Jang E, Scudder S, Manoocheri K, Carter A
Cell Rep
. 2022 Jul;
40(1):111042.
PMID: 35793623
Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) play a central role in motivated behaviors and associated disorders. However, while the activation of ChIs has been well studied in the...
3.
Scudder S, Gonzales F, Howell K, Stein I, Dozier L, Anagnostaras S, et al.
eNeuro
. 2021 Mar;
8(3).
PMID: 33658307
Dynamic control of protein degradation via the ubiquitin proteasome system (UPS) is thought to play a crucial role in neuronal function and synaptic plasticity. The proteasome subunit Rpt6, an AAA...
4.
Scudder S, Baimel C, MacDonald E, Carter A
J Neurosci
. 2018 Sep;
38(42):9091-9104.
PMID: 30185462
The nucleus accumbens (NAc) is critical for motivated behavior and is rewired following exposure to drugs of abuse. Medium spiny neurons (MSNs) in the NAc express either D1 or D2...
5.
Dwyer C, Scudder S, Lin Y, Dozier L, Phan D, Allen N, et al.
Sci Rep
. 2017 Apr;
7:46576.
PMID: 28418018
Sanfilippo syndrome, MPS IIIA-D, results from deficits in lysosomal enzymes that specifically degrade heparan sulfate, a sulfated glycosaminoglycan. The accumulation of heparan sulfate results in neurological symptoms, culminating in extensive...
6.
Rodrigues E, Scudder S, Goo M, Patrick G
J Neurosci
. 2016 Feb;
36(5):1590-5.
PMID: 26843640
Significance Statement: Synaptic changes in Alzheimer's disease (AD) include surface AMPAR loss, which can weaken synapses. In a cell culture model of AD, we found that AMPAR loss correlates with...
7.
Goo M, Scudder S, Patrick G
Front Mol Neurosci
. 2015 Nov;
8:60.
PMID: 26528125
Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of...
8.
Scudder S, Patrick G
Mol Cell Neurosci
. 2015 Feb;
65:52-7.
PMID: 25701678
The posttranslational modification of proteins by the ubiquitin-like small molecule NEDD8 has previously been shown to be vital in a number of cell signaling pathways. In particular, conjugation of NEDD8...
9.
Scudder S, Goo M, Cartier A, Molteni A, Schwarz L, Wright R, et al.
J Neurosci
. 2014 Dec;
34(50):16637-49.
PMID: 25505317
The trafficking of AMPA receptors (AMPARs) to and from synapses is crucial for synaptic plasticity. Previous work has demonstrated that AMPARs undergo activity-dependent ubiquitination by the E3 ubiquitin ligase Nedd4-1,...