Christina J Sigurdson
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Explore the profile of Christina J Sigurdson including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Pfeiffer P, Ugrina M, Schwierz N, Sigurdson C, Schmidt M, Fandrich M
J Mol Biol
. 2023 Dec;
436(4):168422.
PMID: 38158175
Aβ amyloid fibrils from Alzheimer's brain tissue are polymorphic and structurally different from typical in vitro formed Aβ fibrils. Here, we show that brain-derived (ex vivo) fibril structures can be...
2.
Aguilar-Calvo P, Malik A, Sandoval D, Barback C, Orru C, Standke H, et al.
PLoS Pathog
. 2023 Sep;
19(9):e1011487.
PMID: 37747931
Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet...
3.
Phansalkar R, Goodwill V, Nirschl J, De Lillo C, Choi J, Spurlock E, et al.
Acta Neuropathol Commun
. 2023 Sep;
11(1):152.
PMID: 37737191
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head trauma. Brain pathology in CTE is characterized by neuronal loss, gliosis, and a distinctive pattern of neuronal accumulation...
4.
Lawrence J, Aguilar-Calvo P, Ojeda-Juarez D, Khuu H, Soldau K, Pizzo D, et al.
J Neurosci
. 2023 Apr;
43(21):3970-3984.
PMID: 37019623
Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for...
5.
Glynn C, Hernandez E, Gallagher-Jones M, Miao J, Sigurdson C, Rodriguez J
Front Neurosci
. 2022 Nov;
16:960322.
PMID: 36389229
Sequence variation in the β2α2 loop, residues 165-175 of the mammalian prion protein (PrP), influences its structure. To better understand the consequences of sequence variation in this region of the...
6.
Cordano C, Nourbakhsh B, Yiu H, Papinutto N, Caverzasi E, Abdelhak A, et al.
Neurology
. 2022 Aug;
99(15):e1685-e1693.
PMID: 36038272
Background And Objectives: The timing of neurodegeneration in multiple sclerosis (MS) remains unclear. It is critical to understand the dynamics of neuroaxonal loss if we hope to prevent or forestall...
7.
Ojeda-Juarez D, Lawrence J, Soldau K, Pizzo D, Wheeler E, Aguilar-Calvo P, et al.
Neurobiol Dis
. 2022 Jul;
172:105834.
PMID: 35905927
Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion...
8.
Goodwill V, Dryden I, Choi J, De Lillo C, Soldau K, Llibre-Guerra J, et al.
Exp Eye Res
. 2022 Jul;
222:109172.
PMID: 35803332
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most commonly diagnosed human prion disease caused by the abnormal misfolding of the 'cellular' prion protein (PrP) into the transmissible 'scrapie-type' prion form (PrP)....
9.
Aguilar-Calvo P, Sevillano A, Rasool S, Cao K, Randolph L, Rissman R, et al.
J Alzheimers Dis
. 2022 Jun;
88(3):1137-1145.
PMID: 35754278
Background: Neurodegenerative diseases are widespread yet challenging to diagnose and stage antemortem. As an extension of the central nervous system, the eye harbors retina ganglion cells vulnerable to degeneration, and...
10.
Gonias S, Banki M, Azmoon P, Romero H, Sigurdson C, Mantuano E, et al.
J Biol Chem
. 2022 Jan;
298(3):101642.
PMID: 35090893
Exosomes and other extracellular vesicles (EVs) participate in cell-cell communication. Herein, we isolated EVs from human plasma and demonstrated that these EVs activate cell signaling and promote neurite outgrowth in...