Gabriel Birkus
Overview
Explore the profile of Gabriel Birkus including associated specialties, affiliations and a list of published articles.
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Articles
52
Citations
877
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Recent Articles
1.
Klima M, Dejmek M, Duchoslav V, Eisenreichova A, Sala M, Chalupsky K, et al.
Structure
. 2024 Feb;
32(4):433-439.e4.
PMID: 38325369
The cGAS-STING pathway is a crucial part of innate immunity; it serves to detect DNA in the cytoplasm and to defend against certain cancers, viruses, and bacteria. We designed and...
2.
Amador R, Vasseur J, Birkus G, Bignon E, Monari A, Clave G, et al.
Org Lett
. 2024 Jan;
26(4):819-823.
PMID: 38236576
The stimulator of interferon genes (STING) protein plays a crucial role in the activation of the innate immune response. Activation of STING is initiated by cyclic dinucleotides (CDNs) which prompted...
3.
Dejmek M, Brazdova A, Otava T, Polidarova M, Klima M, Smola M, et al.
Eur J Med Chem
. 2023 Aug;
259:115685.
PMID: 37567057
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell damage...
4.
Gilmore S, Tam D, Cheung T, Snyder C, Farand J, Dick R, et al.
PLoS One
. 2022 Dec;
17(12):e0271145.
PMID: 36477212
Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis...
5.
Polidarova M, Vanekova L, Brehova P, Dejmek M, Vavrina Z, Birkus G, et al.
ACS Infect Dis
. 2022 Dec;
9(1):23-32.
PMID: 36472628
Chronic hepatitis B (CHB) remains a major public health problem worldwide, with limited treatment options, but inducing an antiviral response by innate immunity activation may provide a therapeutic alternative. We...
6.
Vavrina Z, Perlikova P, Milisavljevic N, Chevrier F, Smola M, Smith J, et al.
J Med Chem
. 2022 Oct;
65(20):14082-14103.
PMID: 36201304
Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs...
7.
Vanekova L, Polidarova M, Veverka V, Birkus G, Brazdova A
Methods Protoc
. 2022 Sep;
5(5).
PMID: 36136816
The liver is a complex organ that governs many types of metabolisms, including energy metabolism and other cellular processes. The liver also plays a crucial role in important functions in...
8.
Dejmek M, Sala M, Brazdova A, Vanekova L, Smola M, Klima M, et al.
Structure
. 2022 Jun;
30(8):1146-1156.e11.
PMID: 35690061
Stimulator of interferon genes (STING) is an adaptor protein of the cGAS-STING signaling pathway involved in the sensing of cytosolic DNA. It functions as a receptor for cyclic dinucleotides (CDNs)...
9.
Lasek T, Petrova M, Kosiova I, Simak O, Budesinsky M, Kozak J, et al.
Bioorg Med Chem
. 2022 Feb;
58:116654.
PMID: 35153131
No abstract available.
10.
Polidarova M, Brehova P, Dejmek M, Birkus G, Brazdova A
ACS Infect Dis
. 2022 Feb;
8(3):463-471.
PMID: 35132859
The cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) pathway plays a crucial role in inducing an antiviral and antitumor immune response. We studied the effects of synthetic STING agonists on...