Milos Budesinsky
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Explore the profile of Milos Budesinsky including associated specialties, affiliations and a list of published articles.
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160
Citations
643
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Recent Articles
1.
Acikara O, Ataman U, Zidorn C, Cvacka J, Kurtul E, Budesinsky M, et al.
Fitoterapia
. 2024 Dec;
180:106328.
PMID: 39645051
The antioxidant activity of Scorzonera parviflora Jacq. roots were assessed by measuring their ability to scavenge ABTS and DPPH radicals. Bioactivity-guided fractionation was utilized to identify the compound(s) responsible for...
2.
Mrazkova L, Lubos M, Voldrich J, Kuzmova E, Zrubecka D, Gwozdiakova P, et al.
PLoS One
. 2024 Sep;
19(9):e0309726.
PMID: 39264940
Preptin, a 34-amino acid peptide derived from pro-IGF2, is believed to influence various physiological processes, including insulin secretion and the regulation of bone metabolism. Despite its recognized involvement, the precise...
3.
Samal M, Sturm L, Banasiewicz M, Deperasinska I, Kozankiewicz B, Morawski O, et al.
Chem Sci
. 2024 Jun;
15(25):9842-9850.
PMID: 38939154
Helicenes are very attractive chiral non-planar polycyclic aromatic hydrocarbons possessing strong chiroptical properties. However, most of the helicenes absorb light mainly in the ultraviolet region, with only a small segment...
4.
Stepanova S, Andris E, Gutten O, Budesinsky M, Dejmek M, Brehova P, et al.
Electrophoresis
. 2023 Dec;
45(7-8):687-705.
PMID: 38059733
Cyclic dinucleotides (CDNs) are important second messengers in bacteria and eukaryotes. Detailed characterization of their physicochemical properties is a prerequisite for understanding their biological functions. Herein, we examine acid-base and...
5.
Dejmek M, Brazdova A, Otava T, Polidarova M, Klima M, Smola M, et al.
Eur J Med Chem
. 2023 Aug;
259:115685.
PMID: 37567057
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell damage...
6.
Vrkoslav V, Horka P, Jindrich J, Budesinsky M, Cvacka J
Molecules
. 2023 May;
28(9).
PMID: 37175204
Aliphatic hydrocarbons (HCs) are usually analyzed by gas chromatography (GC) or matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. However, analyzing long-chain HCs by GC is difficult because of their low volatility...
7.
Lubos M, Picha J, Selicharova I, Zak J, Budesinsky M, Mitrova K, et al.
J Pept Sci
. 2023 Jan;
29(7):e3478.
PMID: 36633503
Insulin is a peptide responsible for regulating the metabolic homeostasis of the organism; it elicits its effects through binding to the transmembrane insulin receptor (IR). Insulin mimetics with agonistic or...
8.
Janousek J, Rybacek J, Budesinsky M, Pospisil L, Stara I, Stary I
Molecules
. 2022 Nov;
27(21).
PMID: 36364465
The synthesis of a tetrathiafulvalene (TTF) derivative, -[4-({4-[(2,2'-bi-1,3-dithiol-4-ylmethoxy)methyl] phenyl}ethynyl)phenyl] ethanethioate, suitable for the modification of gold nanoparticles (AuNPs), is described in this article. The TTF ligand was self-assembled on the...
9.
Samal M, Rybacek J, Holec J, Hanus J, Vacek J, Budesinsky M, et al.
Chem Commun (Camb)
. 2022 Oct;
58(91):12732-12735.
PMID: 36314481
A series of regioisomeric push-pull amino-nitro [6]helicenes and a related [7]helicene derivative were prepared and their racemates resolved into enantiomers. Compared to the parent helicenes, they exhibit red-shifted UV-Vis spectra,...
10.
Vavrina Z, Perlikova P, Milisavljevic N, Chevrier F, Smola M, Smith J, et al.
J Med Chem
. 2022 Oct;
65(20):14082-14103.
PMID: 36201304
Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs...