Radim Nencka
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Explore the profile of Radim Nencka including associated specialties, affiliations and a list of published articles.
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84
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1353
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Recent Articles
1.
Dusek J, Mejdrova I, Dohnalova K, Smutny T, Chalupsky K, Krutakova M, et al.
Nat Commun
. 2025 Feb;
16(1):1418.
PMID: 39915454
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic clearance but distinct roles in endobiotic metabolism. Car activation has...
2.
Kocek H, Chalupska D, Dejmek M, Dvorakova A, Zgarbova M, Sala M, et al.
RSC Med Chem
. 2024 Sep;
PMID: 39220762
The emergence of SARS-CoV-2, the causative agent of COVID-19, has highlighted the need for advanced antiviral strategies. Targeting the coronaviral methyltransferase nsp14, which is essential for RNA capping, offers a...
3.
Skach K, Boserle J, Nuta G, Brehova P, Bialik S, Carvalho S, et al.
Bioorg Med Chem Lett
. 2024 Sep;
112:129939.
PMID: 39218407
Autophagy is a catabolic process that was described to play a critical role in advanced stages of cancer, wherein it maintains tumor cell homeostasis and growth by supplying nutrients. Autophagy...
4.
Zilecka E, Klima M, Stefek M, Dejmek M, Nencka R, Boura E
J Struct Biol X
. 2024 Aug;
10:100109.
PMID: 39188530
Nsp14 is an RNA methyltransferase (MTase) encoded by all coronaviruses. In fact, many viral families, including DNA viruses, encode MTases that catalyze the methylation of the RNA precap structure, resulting...
5.
Toth L, Krejcova K, Dejmek M, Zilecka E, Klepetarova B, Slavetinska L, et al.
Beilstein J Org Chem
. 2024 May;
20:1029-1036.
PMID: 38746653
The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process. One of the most targeted RNA...
6.
Klima M, Dejmek M, Duchoslav V, Eisenreichova A, Sala M, Chalupsky K, et al.
Structure
. 2024 Feb;
32(4):433-439.e4.
PMID: 38325369
The cGAS-STING pathway is a crucial part of innate immunity; it serves to detect DNA in the cytoplasm and to defend against certain cancers, viruses, and bacteria. We designed and...
7.
Misehe M, Sala M, Matousova M, Hercik K, Kocek H, Chalupska D, et al.
Bioorg Med Chem Lett
. 2023 Nov;
97:129567.
PMID: 38008339
In human cells, receptor-interacting protein kinase 2 (RIPK2) is mainly known to mediate downstream enzymatic cascades from the nucleotide-binding oligomerization domain-containing receptors 1 and 2 (NOD1/2), which are regulators of...
8.
Cermakova K, Tao L, Dejmek M, Sala M, Montierth M, Chan Y, et al.
Nucleic Acids Res
. 2023 Nov;
52(1):4-21.
PMID: 37993417
Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF is acutely essential in these settings has...
9.
Nigam A, Hurley M, Li F, Konkolova E, Klima M, Trylcova J, et al.
bioRxiv
. 2023 Oct;
PMID: 37873443
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant global morbidity and mortality. A crucial viral protein, the non-structural protein 14 (nsp14), catalyzes the methylation of viral...
10.
Inniss N, Kozic J, Li F, Rosas-Lemus M, Minasov G, Rybacek J, et al.
ACS Infect Dis
. 2023 Sep;
9(10):1918-1931.
PMID: 37728236
A collaborative, open-science team undertook discovery of novel small molecule inhibitors of the SARS-CoV-2 nsp16-nsp10 2'--methyltransferase using a high throughput screening approach with the potential to reveal new inhibition strategies....