G I Shulman
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Explore the profile of G I Shulman including associated specialties, affiliations and a list of published articles.
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Articles
165
Citations
13306
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Recent Articles
1.
Weismann D, Erion D, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao J, et al.
Diabetologia
. 2010 Dec;
54(4):935-44.
PMID: 21190014
Aims/hypothesis: Insulin action is purportedly modulated by Drosophila tribbles homologue 3 (TRIB3), which in vitro prevents thymoma viral proto-oncogene (AKT) and peroxisome proliferator-activated receptor-γ (PPAR-γ) activation. However, the physiological impact...
2.
Perseghin G, Petersen K, Shulman G
Int J Obes Relat Metab Disord
. 2004 Jan;
27 Suppl 3:S6-11.
PMID: 14704736
Insulin resistance is a pivotal feature in the pathogenesis of type 2 diabetes, and it may be detected 10-20 y before the clinical onset of hyperglycemia. Insulin resistance is due...
3.
Kernan W, Inzucchi S, Viscoli C, Brass L, Bravata D, Shulman G, et al.
Neurology
. 2003 May;
60(9):1447-51.
PMID: 12743229
Objectives: To determine the prevalence of impaired insulin sensitivity among nondiabetic patients with a recent TIA or nondisabling ischemic stroke. Methods: Eligible subjects were nondiabetic men and women over age...
4.
McCrimmon R, Evans M, Jacob R, Fan X, Zhu Y, Shulman G, et al.
Am J Physiol Endocrinol Metab
. 2002 Oct;
283(5):E1076-83.
PMID: 12376337
Individuals with type 1 diabetes demonstrate a hypoglycemia-specific defect in glucagon secretion. To determine whether intraislet hyperinsulinemia plays a role in the genesis of this defect, glucagon-secretory responses to moderate...
5.
Boden G, Shulman G
Eur J Clin Invest
. 2002 May;
32 Suppl 3:14-23.
PMID: 12028371
Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological consequences. Elevated FFA concentrations are...
6.
Papas K, Colton C, Gounarides J, Roos E, Jarema M, Shapiro M, et al.
Ann N Y Acad Sci
. 2002 Jan;
944:96-119.
PMID: 11797699
Islet transplantation is a promising method for restoring normoglycemia and alleviating the long term complications of diabetes. Widespread application of islet transplantation is hindered by the limited supply of human...
7.
Bergeron R, Ren J, Cadman K, Moore I, Perret P, Pypaert M, et al.
Am J Physiol Endocrinol Metab
. 2001 Nov;
281(6):E1340-6.
PMID: 11701451
The underlying mechanism by which skeletal muscle adapts to exercise training or chronic energy deprivation is largely unknown. To examine this question, rats were fed for 9 wk either with...
8.
Lebon V, Dufour S, Petersen K, Ren J, Jucker B, Slezak L, et al.
J Clin Invest
. 2001 Sep;
108(5):733-7.
PMID: 11544279
The mechanism underlying the regulation of basal metabolic rate by thyroid hormone remains unclear. Although it has been suggested that thyroid hormone might uncouple substrate oxidation from ATP synthesis, there...
9.
Kim J, Kim Y, Fillmore J, Chen Y, Moore I, Lee J, et al.
J Clin Invest
. 2001 Aug;
108(3):437-46.
PMID: 11489937
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and may involve fat-induced activation of a serine kinase cascade involving IKK-beta. To test this hypothesis, we...
10.
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
Fernandez A, Kim J, Yakar S, Dupont J, Hernandez-Sanchez C, Castle A, et al.
Genes Dev
. 2001 Aug;
15(15):1926-34.
PMID: 11485987
Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose disposal in...