D L Rothman
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Explore the profile of D L Rothman including associated specialties, affiliations and a list of published articles.
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164
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7494
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Recent Articles
1.
Chowdhury G, Zhang J, Thomas M, Banasr M, Ma X, Pittman B, et al.
Mol Psychiatry
. 2016 Apr;
22(1):120-126.
PMID: 27067013
Several drugs have recently been reported to induce rapid antidepressant effects in clinical trials and rodent models. Although the cellular mechanisms involved remain unclear, reports suggest that increased glutamate transmission...
2.
Hyder F, Kida I, Behar K, Kennan R, Maciejewski P, Rothman D
NMR Biomed
. 2001 Dec;
14(7-8):413-31.
PMID: 11746934
Quantitative magnetic resonance imaging (MRI) and spectroscopy (MRS) measurements of energy metabolism (i.e. cerebral metabolic rate of oxygen consumption, CMR(O2)), blood circulation (i.e. cerebral blood flow, CBF, and volume, CBV),...
3.
Shulman R, Hyder F, Rothman D
NMR Biomed
. 2001 Dec;
14(7-8):389-96.
PMID: 11746930
In the unstimulated brain energy is primarily supplied by the oxidation of glucose. However the oxygen-to-glucose index (OGI), which is the ratio of metabolic rates of oxygen to glucose, CMR(O2)/CMR(glc),...
4.
Graham G, Hwang J, Rothman D, Prichard J
Stroke
. 2001 Dec;
32(12):2797-802.
PMID: 11739976
Background And Purpose: We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using...
5.
Pan J, Telang F, Lee J, de Graaf R, Rothman D, Stein D, et al.
J Neurochem
. 2001 Nov;
79(3):539-44.
PMID: 11701757
We report the measurement of D-beta-hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo (1)H magnetic resonance (MR)...
6.
Patel A, Rothman D, Cline G, Behar K
Brain Res
. 2001 Nov;
919(2):207-20.
PMID: 11701133
The objective of the present study was to assess the degree to which astrocytic glutamine provides carbon for net synthesis of GABA in the rat neocortex in vivo. Isotopic labeling...
7.
MASON G, Martin D, Martin S, Manor D, Sibson N, Patel A, et al.
Brain Res
. 2001 Oct;
914(1-2):81-91.
PMID: 11578600
gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution of these isoforms to GABA synthesis flux (V(GAD))...
8.
Lebon V, Dufour S, Petersen K, Ren J, Jucker B, Slezak L, et al.
J Clin Invest
. 2001 Sep;
108(5):733-7.
PMID: 11544279
The mechanism underlying the regulation of basal metabolic rate by thyroid hormone remains unclear. Although it has been suggested that thyroid hormone might uncouple substrate oxidation from ATP synthesis, there...
9.
Behar K, Rothman D
J Nutr
. 2001 Sep;
131(9 Suppl):2498S-504S; discussion 2523S-4S.
PMID: 11533301
It has been recognized for many years that the metabolism of brain glutamate and gamma-aminobutyric acid (GABA), the major excitatory and inhibitory neurotransmitters, is linked to a substrate cycle between...
10.
de Graaf R, Rothman D
J Magn Reson
. 2001 Sep;
152(1):124-31.
PMID: 11531371
Two novel spectral editing techniques for the in vivo detection of gamma-aminobutyric acid (GABA) are presented. The techniques rely on the generation of longitudinal scalar order (LSO) coherences, which in...