R G Shulman
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Explore the profile of R G Shulman including associated specialties, affiliations and a list of published articles.
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295
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Recent Articles
1.
Shulman R
IUBMB Life
. 2002 Jan;
51(6):351-7.
PMID: 11758802
Structural biology is based on the assumption that structural determinations will explain macromolecular function. To examine the basis of these proposals, the structure/function connections in hemoglobin have been examined. Presently...
2.
Shulman R, Hyder F, Rothman D
NMR Biomed
. 2001 Dec;
14(7-8):389-96.
PMID: 11746930
In the unstimulated brain energy is primarily supplied by the oxidation of glucose. However the oxygen-to-glucose index (OGI), which is the ratio of metabolic rates of oxygen to glucose, CMR(O2)/CMR(glc),...
3.
Shulman R, Hyder F, Rothman D
Proc Natl Acad Sci U S A
. 2001 May;
98(11):6417-22.
PMID: 11344262
Positron-emission tomography and functional MRS imaging signals can be analyzed to derive neurophysiological values of cerebral blood flow or volume and cerebral metabolic consumption rates of glucose (CMR(Glc)) or oxygen...
4.
Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo 13C/31P NMR spectroscopy
Chase J, Rothman D, Shulman R
Am J Physiol Endocrinol Metab
. 2001 Mar;
280(4):E598-607.
PMID: 11254467
To determine the relative contributions of glucose transport/hexokinase, glycogen synthase (GSase), and glycolysis to the control of insulin-stimulated muscle glycogen synthesis, we combined 13C and 31P NMR to quantitate the...
5.
Shulman R, Rothman D
Proc Natl Acad Sci U S A
. 2001 Feb;
98(2):457-61.
PMID: 11209049
Stimulated by recent (13)C and (31)P NMR studies of exercising muscle, we propose a model of the energetics of contraction. Previous studies of energetics have followed energy consumption. However, the...
6.
Shulman R, Rothman D
Annu Rev Physiol
. 2001 Feb;
63:15-48.
PMID: 11181947
The study of intermediary metabolism in biomolecules has been given new directions by recent experiments in human muscle and brain by 13C NMR. Labeled substrates, generally glucose, have enabled the...
7.
Sibson N, MASON G, Shen J, Cline G, Herskovits A, Wall J, et al.
J Neurochem
. 2001 Feb;
76(4):975-89.
PMID: 11181817
The aims of this study were twofold: (i) to determine quantitatively the contribution of glutamate/glutamine cycling to total astrocyte/neuron substrate trafficking for the replenishment of neurotransmitter glutamate; and (ii) to...
8.
Shulman R
Am J Psychiatry
. 2001 Jan;
158(1):11-20.
PMID: 11136626
Objective: The imaging of brain activity with positron emission tomography (PET) and functional magnetic resonance imaging has assumed a central position in psychiatry. Functional imaging signals arise from changes in...
9.
Xu F, Kida I, Hyder F, Shulman R
Proc Natl Acad Sci U S A
. 2000 Sep;
97(19):10601-6.
PMID: 10973488
Dynamic blood oxygenation level-dependent functional MRI was applied at 7 T in the rat olfactory bulb (OB) with pulsed delivery of iso-amyl acetate (IAA) and limonene. Acquisition times for single-slice...
10.
Price T, Rothman D, Shulman R
Proc Nutr Soc
. 2000 May;
58(4):851-9.
PMID: 10817152
Natural-abundance 13C NMR spectroscopy is a non-invasive technique that enables in vivo assessments of muscle and/or liver glycogen concentrations. Over the last several years, 13C NMR has been developed and...