Erik Westein
Overview
Explore the profile of Erik Westein including associated specialties, affiliations and a list of published articles.
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25
Citations
1169
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0
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Recent Articles
1.
Hoefer T, Rana A, Niego B, Jagdale S, Albers H, Gardiner E, et al.
Haematologica
. 2020 Oct;
106(11):2874-2884.
PMID: 33054112
Intraluminal thrombus formation precipitates conditions such as acute myocardial infarction and disturbs local blood flow resulting in areas of rapidly changing blood flow velocities and steep gradients of blood shear...
2.
Rana A, Westein E, Niego B, Hagemeyer C
Front Cardiovasc Med
. 2019 Oct;
6:141.
PMID: 31620451
Cardiovascular diseases (CVD) are the number one cause of morbidity and death worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a staggering 85%...
3.
Palazzolo J, Westein E, Hagemeyer C, Wang T
Semin Thromb Hemost
. 2019 Oct;
46(5):606-621.
PMID: 31614390
Thrombosis is characterized by the formation of in vivo blood clots that are localized within arterial or venous blood vessels. These thrombi form beyond the need for physiologically healthy hemostatic...
4.
Westein E, Hoefer T, Calkin A
Clin Sci (Lond)
. 2017 Jun;
131(12):1245-1260.
PMID: 28592700
Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes (T2D). This condition is associated with heightened platelet reactivity, contributing to increased atherothrombotic risk. Indeed, individuals...
5.
Kraakman M, Lee M, Al-Sharea A, Dragoljevic D, Barrett T, Montenont E, et al.
J Clin Invest
. 2017 May;
127(6):2133-2147.
PMID: 28504650
Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia, processes that are accelerated in diabetes. Whether hyperglycemia promotes platelet production and whether enhanced platelet production contributes to enhanced...
6.
Wu Z, Rademakers T, Kiessling F, Vogt M, Westein E, Weber C, et al.
Methods
. 2017 Apr;
130:79-89.
PMID: 28434997
Multiphoton laser scanning microscopy has proven profound value for ex vivo 3D histology and in vivo imaging of motionless tissue. The development of triggering systems and fast imaging methods, combined...
7.
Gunawan S, Kempe K, Bonnard T, Cui J, Alt K, Law L, et al.
Adv Mater
. 2015 Aug;
27(35):5153-7.
PMID: 26239035
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen...
8.
Alt K, Paterson B, Westein E, Rudd S, Poniger S, Jagdale S, et al.
Angew Chem Int Ed Engl
. 2015 May;
54(26):7515-9.
PMID: 25962581
A unique two-step modular system for site-specific antibody modification and conjugation is reported. The first step of this approach uses enzymatic bioconjugation with the transpeptidase Sortase A for incorporation of...
9.
Wang X, Palasubramaniam J, Gkanatsas Y, Hohmann J, Westein E, Kanojia R, et al.
Circ Res
. 2014 Feb;
114(7):1083-93.
PMID: 24508759
Rationale: Fibrinolysis is a valuable alternative for the treatment of myocardial infarction when percutaneous coronary intervention is not available in a timely fashion. For acute ischemic stroke, fibrinolysis is the...
10.
Hughan S, Spring C, Schoenwaelder S, Sturgeon S, Alwis I, Yuan Y, et al.
J Biol Chem
. 2014 Jan;
289(8):5051-60.
PMID: 24385425
The Dok proteins are a family of adaptor molecules that have a well defined role in regulating cellular migration, immune responses, and tumor progression. Previous studies have demonstrated that Doks-1...