Shaun P Jackson
Overview
Explore the profile of Shaun P Jackson including associated specialties, affiliations and a list of published articles.
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109
Citations
4309
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Recent Articles
1.
Dockerill M, Ford D, Angerani S, Alwis I, Dowman L, Ripoll-Rozada J, et al.
Nat Biotechnol
. 2024 Apr;
43(2):186-193.
PMID: 38689027
Drugs are administered at a dosing schedule set by their therapeutic index, and termination of action is achieved by clearance and metabolism of the drug. In some cases, such as...
2.
Guan I, Liu J, Sawyer R, Li X, Jiao W, Jiramongkol Y, et al.
ACS Cent Sci
. 2024 Mar;
10(2):344-357.
PMID: 38435523
A large variety of dietary phytochemicals has been shown to improve thrombosis and stroke outcomes in preclinical studies. Many of these compounds feature electrophilic functionalities that potentially undergo covalent addition...
3.
Ellis M, Terreaux A, Alwis I, Smythe R, Perdomo J, Eckly A, et al.
Blood
. 2023 Nov;
143(4):342-356.
PMID: 37922495
Glycoprotein Ibα (GPIbα) is expressed on the surface of platelets and megakaryocytes (MKs) and anchored to the membrane skeleton by filamin A (flnA). Although GPIb and flnA have fundamental roles...
4.
Lay A, Dupuy A, Hagimola L, Tieng J, Larance M, Zhang Y, et al.
Blood Adv
. 2022 Dec;
7(9):1650-1665.
PMID: 36508284
Extracellular protein disulfide isomerases (PDIs), including PDI, endoplasmic reticulum protein 57 (ERp57), ERp72, ERp46, and ERp5, are required for in vivo thrombus formation in mice. Platelets secrete PDIs upon activation,...
5.
Ellis M, Alwis I, Smythe R, Yuan Y, Jackson S
Blood Adv
. 2022 Nov;
7(6):982-986.
PMID: 36355836
No abstract available.
6.
Maclean J, Tomkins A, Sturgeon S, Hofma B, Alwis I, Samson A, et al.
Blood Adv
. 2022 Jun;
6(18):5449-5462.
PMID: 35767737
Recanalization with restored cerebral perfusion is the primary goal of thrombolytic therapy in acute ischemic stroke. The identification of adjunctive therapies that can be safely used to enhance thrombolysis in...
7.
Ju L, Kossmann S, Zhao Y, Moldovan L, Zhang Y, De Zoysa Ramasundara S, et al.
Analyst
. 2022 Feb;
147(6):1222-1235.
PMID: 35212697
Microvascular thrombosis and inflammation (thromboinflammation) are major causes of morbidity and mortality in critically ill patients with limited therapeutic options. Platelets are central to thromboinflammation, and microvascular platelet thrombi are...
8.
Agten S, Watson E, Ripoll-Rozada J, Dowman L, Wu M, Alwis I, et al.
Angew Chem Int Ed Engl
. 2020 Dec;
60(10):5348-5356.
PMID: 33345438
Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by...
9.
Obeidy P, Ju L, Oehlers S, Zulkhernain N, Lee Q, Galeano Nino J, et al.
Immunol Cell Biol
. 2019 Nov;
98(2):93-113.
PMID: 31698518
T lymphocytes utilize amoeboid migration to navigate effectively within complex microenvironments. The precise rearrangement of the actin cytoskeleton required for cellular forward propulsion is mediated by actin regulators, including the...
10.
Watson E, Ripoll-Rozada J, Lee A, Wu M, Franck C, Pasch T, et al.
Proc Natl Acad Sci U S A
. 2019 Jun;
116(28):13873-13878.
PMID: 31221752
Hematophagous organisms produce a suite of salivary proteins which interact with the host's coagulation machinery to facilitate the acquisition and digestion of a bloodmeal. Many of these biomolecules inhibit the...