Warwick S Nesbitt
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Explore the profile of Warwick S Nesbitt including associated specialties, affiliations and a list of published articles.
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30
Citations
1012
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Recent Articles
1.
George A, Akbaridoust F, Zainal Abidin N, Nesbitt W, Marusic I
Lab Chip
. 2023 Jun;
23(13):3092-3105.
PMID: 37305977
Hydrodynamic trapping of a particle or cluster of particles based on contact and non-contact approaches has brought prominent insights to micro-nano scale applications. Of the non-contact methods, image-based real-time control...
2.
Zainal Abidin N, Timofeeva M, Szydzik C, Akbaridoust F, Lav C, Marusic I, et al.
Res Pract Thromb Haemost
. 2023 Feb;
7(1):100037.
PMID: 36846647
Background: Blood platelets have evolved a complex mechanotransduction machinery to rapidly respond to hemodynamic conditions. A variety of microfluidic flow-based approaches have been developed to explore platelet mechanotransduction; however, these...
3.
Zainal Abidin N, Poon E, Szydzik C, Timofeeva M, Akbaridoust F, Brazilek R, et al.
BMC Biol
. 2022 Mar;
20(1):73.
PMID: 35331224
Background: Supraphysiological hemodynamics are a recognized driver of platelet activation and thrombosis at high-grade stenosis and in blood contacting circulatory support devices. However, whether platelets mechano-sense hemodynamic parameters directly in...
4.
Selvadurai M, Moon M, Mountford S, Ma X, Zheng Z, Jennings I, et al.
Sci Transl Med
. 2020 Jul;
12(553).
PMID: 32718993
Arterial thrombosis causes heart attacks and most strokes and is the most common cause of death in the world. Platelets are the cells that form arterial thrombi, and antiplatelet drugs...
5.
Szydzik C, Brazilek R, Nesbitt W
Semin Thromb Hemost
. 2020 Jul;
46(5):622-636.
PMID: 32604421
The manipulation of blood within in vitro environments presents a persistent challenge, due to the highly reactive nature of blood, and its multifaceted response to material contact, changes in environmental...
6.
Mangin P, Gardiner E, Nesbitt W, Kerrigan S, Korin N, Lam W, et al.
J Thromb Haemost
. 2020 Mar;
18(3):748-752.
PMID: 32112535
Experimental videomicroscopic in vitro assays of thrombus formation based on blood perfusion are instrumental in a wide range of basic studies in thrombosis, screening for hereditary or acquired plateletrelated pathologies,...
7.
Szydzik C, Brazilek R, Akbaridoust F, de Silva C, Moon M, Marusic I, et al.
Anal Chem
. 2019 Jul;
91(16):10830-10839.
PMID: 31343155
There is a need for scalable automated lab-on-chip systems incorporating precise hemodynamic control that can be applied to high-content screening of new more efficacious antiplatelet therapies. This paper reports on...
8.
Sashindranath M, Sturgeon S, French S, Craenmehr D, Selan C, Freddi S, et al.
Res Pract Thromb Haemost
. 2019 Apr;
3(2):197-206.
PMID: 31011704
Background: Arterial thrombosis models are important for preclinical evaluation of antithrombotics but how anesthetic protocol can influence experimental results is not studied. Objectives: We studied how three most commonly used...
9.
Selvadurai M, Brazilek R, Moon M, Rinckel J, Eckly A, Gachet C, et al.
FEBS Lett
. 2018 Nov;
593(1):88-96.
PMID: 30421419
PI3KC2α is a phosphoinositide 3-kinase with a recently reported function in platelets; PI3KC2α-deficient mouse platelets have altered membrane structure and impaired function. Yet, how these membrane changes cause platelet dysfunction...
10.
Szydzik C, Brazilek R, Khoshmanesh K, Akbaridoust F, Knoerzer M, Thurgood P, et al.
Lab Chip
. 2018 May;
18(12):1778-1792.
PMID: 29789838
This paper reports on the parameters that determine the haemocompatibility of elastomeric microvalves for blood handling in microfluidic systems. Using a comprehensive investigation of blood function, we describe a hierarchy...