Erik Westein
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Explore the profile of Erik Westein including associated specialties, affiliations and a list of published articles.
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25
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1169
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Recent Articles
11.
Nesbitt W, Tovar-Lopez F, Westein E, Harper I, Jackson S
Methods Mol Biol
. 2013 Jul;
1046:39-58.
PMID: 23868581
Fluorescence microscopy techniques have provided important insights into the structural and signalling events occurring during platelet adhesion under both static and blood flow conditions. However, due to limitations in sectioning...
12.
Ghasemzadeh M, Kaplan Z, Alwis I, Schoenwaelder S, Ashworth K, Westein E, et al.
Blood
. 2013 Apr;
121(22):4555-66.
PMID: 23550035
Thrombosis promotes leukocyte infiltration into inflamed tissues, leading to organ injury in a broad range of diseases; however, the mechanisms by which thrombi guide leukocytes to sites of vascular injury...
13.
Westein E, van der Meer A, Kuijpers M, Frimat J, van den Berg A, Heemskerk J
Proc Natl Acad Sci U S A
. 2013 Jan;
110(4):1357-62.
PMID: 23288905
Rupture of a vulnerable atherosclerotic plaque causes thrombus formation and precipitates cardiovascular diseases. In addition to the thrombogenic content of a plaque, also the hemodynamic microenvironment plays a major role...
14.
Westein E, de Witt S, Lamers M, Cosemans J, Heemskerk J
Platelets
. 2012 Aug;
23(7):501-9.
PMID: 22873212
Cardiovascular disease is a major cause of mortality globally and is subject to ongoing research to improve clinical treatment. It is established that activation of platelets and coagulation are central...
15.
Straub A, Krajewski S, Hohmann J, Westein E, Jia F, Bassler N, et al.
Arterioscler Thromb Vasc Biol
. 2011 Apr;
31(7):1607-16.
PMID: 21512161
Objective: Hypothermia is used in various clinical settings to inhibit ischemia-related organ damage. However, prothrombotic effects have been described as potential side effects. This study aimed to elucidate the mechanism...
16.
Tovar-Lopez F, Rosengarten G, Khoshmanesh K, Westein E, Jackson S, Nesbitt W, et al.
J Biomech
. 2011 Mar;
44(6):1031-9.
PMID: 21392770
Platelet activation under blood flow is thought to be critically dependent on the autologous secretion of soluble platelet agonists (chemical activators) such as ADP and thromboxane. However, recent evidence challenging...
17.
Devi S, Kuligowski M, Kwan R, Westein E, Jackson S, Kitching A, et al.
Am J Pathol
. 2010 Jul;
177(3):1131-42.
PMID: 20651232
Recruitment of leukocytes to glomeruli is fundamental to the pathogenesis of many forms of glomerulonephritis. In a model of glomerulonephritis induced by in situ immune complex deposition, we previously observed...
18.
Tovar-Lopez F, Rosengarten G, Westein E, Khoshmanesh K, Jackson S, Mitchell A, et al.
Lab Chip
. 2010 Jan;
10(3):291-302.
PMID: 20091000
This paper reports the development of a platform technology for measuring platelet function and aggregation based on localized strain rate micro-gradients. Recent experimental findings within our laboratories have identified a...
19.
Nesbitt W, Westein E, Tovar-Lopez F, Tolouei E, Mitchell A, Fu J, et al.
Nat Med
. 2009 May;
15(6):665-73.
PMID: 19465929
Platelet aggregation at sites of vascular injury is essential for hemostasis and arterial thrombosis. It has long been assumed that platelet aggregation and thrombus growth are initiated by soluble agonists...
20.
Ono A, Westein E, Hsiao S, Nesbitt W, Hamilton J, Schoenwaelder S, et al.
Blood
. 2008 Mar;
112(1):90-9.
PMID: 18310501
A fundamental property of platelets is their ability to transmit cytoskeletal contractile forces to extracellular matrices. While the importance of the platelet contractile mechanism in regulating fibrin clot retraction is...