Emily C Wheeler
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Explore the profile of Emily C Wheeler including associated specialties, affiliations and a list of published articles.
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18
Citations
524
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Recent Articles
1.
Wheeler E, Martin B, Doyle W, Neaher S, Conway C, Pitton C, et al.
Sci Transl Med
. 2024 Jan;
16(728):eade2774.
PMID: 38170787
Splicing modulation is a promising treatment strategy pursued to date only in splicing factor-mutant cancers; however, its therapeutic potential is poorly understood outside of this context. Like splicing factors, genes...
2.
Krach F, Wheeler E, Regensburger M, Boerstler T, Wend H, Vu A, et al.
Acta Neuropathol
. 2022 Jul;
144(3):413-435.
PMID: 35778567
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by aberrant alternative splicing (AS). Nuclear loss and cytoplasmic accumulation of the splicing factor TDP-43 in motor neurons (MN) are hallmarks...
3.
Oreskovic E, Wheeler E, Mengwasser K, Fujimura E, Martin T, Tothova Z, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(7).
PMID: 35149558
Immune evasion is a significant contributor to tumor evolution, and the immunoinhibitory axis PD-1/PD-L1 is a frequent mechanism employed to escape tumor immune surveillance. To identify cancer drivers involved in...
4.
Wheeler E, Vora S, Mayer D, Kotini A, Olszewska M, Park S, et al.
Cancer Discov
. 2021 Oct;
12(3):836-855.
PMID: 34620690
Significance: SF mutations are disease-defining in MDS, but their critical effectors remain unknown. We discover the first direct target of convergent missplicing by mutant U2AF1 and SRSF2, a long GNAS...
5.
Tan F, Sathe S, Wheeler E, Yeo G
Cell Rep
. 2021 Aug;
36(6):109517.
PMID: 34380031
RNA binding protein (RBP) expression is finite. For RBPs that are vastly outnumbered by their potential target sites, a simple competition for binding can set the magnitude of post-transcriptional control....
6.
Marcheva B, Perelis M, Weidemann B, Taguchi A, Lin H, Omura C, et al.
Genes Dev
. 2021 Mar;
35(5-6):425.
PMID: 33649163
No abstract available.
7.
Trujillo C, Rice E, Schaefer N, Chaim I, Wheeler E, Madrigal A, et al.
Science
. 2021 Feb;
371(6530).
PMID: 33574182
The evolutionarily conserved splicing regulator neuro-oncological ventral antigen 1 () plays a key role in neural development and function. also includes a protein-coding difference between the modern human genome and...
8.
Reilly B, Luger T, Park S, Lio C, Gonzalez-Avalos E, Wheeler E, et al.
Mol Cancer Res
. 2020 Nov;
19(3):451-464.
PMID: 33172974
DNA methyltransferase inhibitors (DNMTI) like 5-Azacytidine (5-Aza) are the only disease-modifying drugs approved for the treatment of higher-risk myelodysplastic syndromes (MDS), however less than 50% of patients respond, and there...
9.
Marcheva B, Perelis M, Weidemann B, Taguchi A, Lin H, Omura C, et al.
Genes Dev
. 2020 Jul;
34(15-16):1089-1105.
PMID: 32616519
The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing...
10.
Wheeler E, Vu A, Einstein J, DiSalvo M, Ahmed N, Van Nostrand E, et al.
Nat Methods
. 2020 May;
17(6):636-642.
PMID: 32393832
Genetic screens using pooled CRISPR-based approaches are scalable and inexpensive, but restricted to standard readouts, including survival, proliferation and sortable markers. However, many biologically relevant cell states involve cellular and...