Eric L Van Nostrand
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Explore the profile of Eric L Van Nostrand including associated specialties, affiliations and a list of published articles.
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49
Citations
4587
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Recent Articles
1.
Song Z, Bae B, Schnabl S, Yuan F, De Zoysa T, Akinyi M, et al.
Genome Biol
. 2025 Feb;
26(1):39.
PMID: 40001124
Background: Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosomal RNA...
2.
Glasner D, Todd C, Cook B, DUrso A, Khosla S, Estrada E, et al.
bioRxiv
. 2025 Feb;
PMID: 39990370
Recognition of "non-self" nucleic acids, including cytoplasmic dsDNA, dsRNA, or mRNAs lacking proper 5' cap structures, is critical for the innate immune response to viruses. Here, we demonstrate that short...
3.
Bhola M, Abe K, Orozco P, Rahnamoun H, Avila-Lopez P, Taylor E, et al.
Mol Cell
. 2024 Aug;
84(17):3192-3208.e11.
PMID: 39173639
Topoisomerase I (TOP1) is an essential enzyme that relaxes DNA to prevent and dissipate torsional stress during transcription. However, the mechanisms underlying the regulation of TOP1 activity remain elusive. Using...
4.
Kodali S, Proietti L, Valcarcel G, Lopez-Rubio A, Pessina P, Eder T, et al.
Nat Cell Biol
. 2024 Aug;
26(10):1745-1758.
PMID: 39169219
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through...
5.
Zheng R, Dunlap M, Bobkov G, Gonzalez-Figueroa C, Patel K, Lyu J, et al.
Mol Cell
. 2024 May;
84(11):2087-2103.e8.
PMID: 38815579
RNA splicing is pivotal in post-transcriptional gene regulation, yet the exponential expansion of intron length in humans poses a challenge for accurate splicing. Here, we identify hnRNPM as an essential...
6.
Xu A, Liu M, Huang M, Zhang Y, Hu R, Gingold J, et al.
Nat Commun
. 2023 Mar;
14(1):1694.
PMID: 36973285
N6-methyladenosine (mA), one of the most prevalent mRNA modifications in eukaryotes, plays a critical role in modulating both biological and pathological processes. However, it is unknown whether mutant p53 neomorphic...
7.
Arif W, Mathur B, Saikali M, Chembazhi U, Toohill K, Song Y, et al.
Nat Commun
. 2023 Feb;
14(1):551.
PMID: 36759613
Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is...
8.
Benoit Bouvrette L, Wang X, Boulais J, Kong J, Uddin Syed E, Blue S, et al.
Nucleic Acids Res
. 2022 Nov;
51(D1):D1549-D1557.
PMID: 36321651
RNA binding proteins (RBPs) are central regulators of gene expression implicated in all facets of RNA metabolism. As such, they play key roles in cellular physiology and disease etiology. Since...
9.
Moore J, Purcaro M, Pratt H, Epstein C, Shoresh N, Adrian J, et al.
Nature
. 2022 Apr;
605(7909):E3.
PMID: 35474001
No abstract available.
10.
Blue S, Yee B, Pratt G, Mueller J, Park S, Shishkin A, et al.
Nat Protoc
. 2022 Mar;
17(5):1223-1265.
PMID: 35322209
Discovery of interaction sites between RNA-binding proteins (RBPs) and their RNA targets plays a critical role in enabling our understanding of how these RBPs control RNA processing and regulation. Cross-linking...