Brian A Yee
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Explore the profile of Brian A Yee including associated specialties, affiliations and a list of published articles.
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39
Citations
1287
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Recent Articles
1.
Glasner D, Todd C, Cook B, DUrso A, Khosla S, Estrada E, et al.
bioRxiv
. 2025 Feb;
PMID: 39990370
Recognition of "non-self" nucleic acids, including cytoplasmic dsDNA, dsRNA, or mRNAs lacking proper 5' cap structures, is critical for the innate immune response to viruses. Here, we demonstrate that short...
2.
Kim H, Mizrahi O, Lee W, Rosenthal S, Han C, Yee B, et al.
bioRxiv
. 2025 Jan;
PMID: 39868246
Highlights: LARP6 is upregulated in liver fibrosis, mainly in HSCs.LARP6 knockdown in human HSCs reduces liver fibrosis development.Of the hundreds of gene targets, LARP6 interacts most with collagen mRNAs.LARP6 regulates...
3.
Megagiannis P, Mei Y, Yan R, Yuan L, Wilde J, Eckersberg H, et al.
Cell Rep
. 2024 Aug;
43(8):114637.
PMID: 39154337
Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes....
4.
Liang Q, Yu T, Kofman E, Jagannatha P, Rhine K, Yee B, et al.
Nat Commun
. 2024 Aug;
15(1):7067.
PMID: 39152130
RNA-binding proteins (RBPs) have pivotal functions in RNA metabolism, but current methods are limited in retrieving RBP-RNA interactions within endogenous biological contexts. Here, we develop INSCRIBE (IN situ Sensitive Capture...
5.
Jagannatha P, Tankka A, Lorenz D, Yu T, Yee B, Brannan K, et al.
Genome Res
. 2024 Jun;
34(11):2012-2024.
PMID: 38906680
Transcription and translation are intertwined processes in which mRNA isoforms are crucial intermediaries. However, methodological limitations in analyzing translation at the mRNA isoform level have left gaps in our understanding...
6.
Lin L, Zhao J, Kubota N, Li Z, Lam Y, Nguyen L, et al.
Neuron
. 2024 May;
112(13):2157-2176.e12.
PMID: 38697111
Mutations in human nonsense-mediated mRNA decay (NMD) factors are enriched in neurodevelopmental disorders. We show that deletion of key NMD factor Upf2 in mouse embryonic neural progenitor cells causes perinatal...
7.
Xu S, Nguyen G, Naritomi J, Kopalle H, Yee B, Rothamel K, et al.
STAR Protoc
. 2024 Apr;
5(2):103040.
PMID: 38669139
Here, we present a protocol for using Skipper, a pipeline designed to process crosslinking and immunoprecipitation (CLIP) data into annotated binding sites. We describe steps for partitioning annotated transcript regions...
8.
Enustun E, Armbruster E, Lee J, Zhang S, Yee B, Malukhina K, et al.
Nucleic Acids Res
. 2024 Mar;
52(8):4440-4455.
PMID: 38554115
Large-genome bacteriophages (jumbo phages) of the proposed family Chimalliviridae assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and DNA-targeting...
9.
Busa V, Ando Y, Aigner S, Yee B, Yeo G, Leung A
iScience
. 2024 Mar;
27(4):109251.
PMID: 38495826
The RNA-binding protein PARP13 is a primary factor in the innate antiviral response, which suppresses translation and drives decay of bound viral and host RNA. PARP13 interacts with many proteins...
10.
Enustun E, Armbruster E, Lee J, Zhang S, Yee B, Gu Y, et al.
bioRxiv
. 2023 Oct;
PMID: 37790334
Large-genome bacteriophages (jumbo phages) of the family assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and CRISPR/Cas nucleases. While...