Elyse C Freiberger
Overview
Explore the profile of Elyse C Freiberger including associated specialties, affiliations and a list of published articles.
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9
Citations
302
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Recent Articles
1.
Freiberger E, Thompson M, Zhang X, Underwood E, Lynch T, Jenkins G, et al.
Drug Metab Dispos
. 2024 Oct;
52(12):1373-1378.
PMID: 39433437
In vitro systems such as cultured hepatocytes are used early in drug development as a proxy for in vivo data to predict metabolites in human and the potential preclinical species....
2.
Dawson A, Wilson G, Freiberger E, Mondal A, Coon J, Mehle A
PLoS Pathog
. 2020 Sep;
16(9):e1008841.
PMID: 32881973
The influenza virus polymerase transcribes and replicates the viral genome. The proper timing and balance of polymerase activity is important for successful replication. Genome replication is controlled in part by...
3.
Stefely J, Zhang Y, Freiberger E, Kwiecien N, Thomas H, Davis A, et al.
Autophagy
. 2020 Jan;
16(12):2219-2237.
PMID: 31971854
Macroautophagy/autophagy is suppressed by MTOR (mechanistic target of rapamycin kinase) and is an anticancer target under active investigation. Yet, MTOR-regulated autophagy remains incompletely mapped. We used proteomic profiling to identify...
4.
Mitok K, Freiberger E, Schueler K, Rabaglia M, Stapleton D, Kwiecien N, et al.
J Biol Chem
. 2018 Mar;
293(16):5860-5877.
PMID: 29496998
The mouse is a critical model in diabetes research, but most research in mice has been limited to a small number of mouse strains and limited genetic variation. Using the...
5.
Veling M, Reidenbach A, Freiberger E, Kwiecien N, Hutchins P, Drahnak M, et al.
Mol Cell
. 2017 Dec;
68(5):970-977.e11.
PMID: 29220658
Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions, although their direct substrates are often difficult to discern. Through multi-omic profiling of diverse Saccharomyces cerevisiae mitoprotease deletion strains,...
6.
Mondal A, Dawson A, Potts G, Freiberger E, Baker S, Moser L, et al.
Elife
. 2017 Aug;
6.
PMID: 28758638
Influenza virus expresses transcripts early in infection and transitions towards genome replication at later time points. This process requires de novo assembly of the viral replication machinery, large ribonucleoprotein complexes...
7.
Stefely J, Kwiecien N, Freiberger E, Richards A, Jochem A, Rush M, et al.
Nat Biotechnol
. 2016 Nov;
34(11):1191-1197.
PMID: 27669165
Mitochondrial dysfunction is associated with many human diseases, including cancer and neurodegeneration, that are often linked to proteins and pathways that are not well-characterized. To begin defining the functions of...
8.
Stefely J, Licitra F, Laredj L, Reidenbach A, Kemmerer Z, Grangeray A, et al.
Mol Cell
. 2016 Aug;
63(4):608-620.
PMID: 27499294
The UbiB protein kinase-like (PKL) family is widespread, comprising one-quarter of microbial PKLs and five human homologs, yet its biochemical activities remain obscure. COQ8A (ADCK3) is a mammalian UbiB protein...
9.
Xue L, Blythe E, Freiberger E, Mamrosh J, Hebert A, Reitsma J, et al.
Mol Cell Proteomics
. 2016 Jul;
15(9):2970-86.
PMID: 27406709
Protein quality control (PQC) plays an important role in stemming neurodegenerative diseases and is essential for the growth of some cancers. Valosin-containing protein (VCP)/p97 plays a pivotal role in multiple...