Adam Jochem
Overview
Explore the profile of Adam Jochem including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
875
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Recent Articles
1.
Rensvold J, Shishkova E, Sverchkov Y, Miller I, Cetinkaya A, Pyle A, et al.
Nature
. 2022 May;
606(7913):382-388.
PMID: 35614220
Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles and have linked their dysfunction to more than...
2.
Kemmerer Z, Robinson K, Schmitz J, Manicki M, Paulson B, Jochem A, et al.
Nat Commun
. 2021 Aug;
12(1):4769.
PMID: 34362905
Beyond its role in mitochondrial bioenergetics, Coenzyme Q (CoQ, ubiquinone) serves as a key membrane-embedded antioxidant throughout the cell. However, how CoQ is mobilized from its site of synthesis on...
3.
Robinson D, Place M, Hose J, Jochem A, Gasch A
Elife
. 2021 Aug;
10.
PMID: 34338637
Copy number variation through gene or chromosome amplification provides a route for rapid phenotypic variation and supports the long-term evolution of gene functions. Although the evolutionary importance of copy-number variation...
4.
Robinson K, Jochem A, Johnson S, Reddy T, Russell J, Coon J, et al.
J Biol Chem
. 2021 Apr;
296:100643.
PMID: 33862086
Coenzyme Q (CoQ), a redox-active lipid essential for oxidative phosphorylation, is synthesized by virtually all cells, but how eukaryotes make the universal CoQ head group precursor 4-hydroxybenzoate (4-HB) from tyrosine...
5.
He Y, Rashan E, Linke V, Shishkova E, Hebert A, Jochem A, et al.
Anal Chem
. 2021 Feb;
93(9):4217-4222.
PMID: 33617230
Mass spectrometry (MS) serves as the centerpiece technology for proteome, lipidome, and metabolome analysis. To gain a better understanding of the multifaceted networks of myriad regulatory layers in complex organisms,...
6.
Subramanian K, Jochem A, Le Vasseur M, Lewis S, Paulson B, Reddy T, et al.
J Cell Biol
. 2019 Jan;
218(4):1353-1369.
PMID: 30674579
Coenzyme Q (CoQ) lipids are ancient electron carriers that, in eukaryotes, function in the mitochondrial respiratory chain. In mitochondria, CoQ lipids are built by an inner membrane-associated, multicomponent, biosynthetic pathway...
7.
Lohman D, Aydin D, Von Bank H, Smith R, Linke V, Weisenhorn E, et al.
Mol Cell
. 2019 Jan;
73(4):763-774.e10.
PMID: 30661980
The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors-among nature's most hydrophobic molecules-must somehow be presented to a...
8.
Schaffer L, Rensvold J, Shortreed M, Cesnik A, Jochem A, Scalf M, et al.
J Proteome Res
. 2018 Sep;
17(10):3526-3536.
PMID: 30180576
The development of effective strategies for the comprehensive identification and quantification of proteoforms in complex systems is a critical challenge in proteomics. Proteoforms, the specific molecular forms in which proteins...
9.
Jha P, McDevitt M, Gupta R, Quiros P, Williams E, Gariani K, et al.
Cell Syst
. 2018 Jun;
6(6):722-733.e6.
PMID: 29909277
The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from...
10.
Jha P, McDevitt M, Halilbasic E, Williams E, Quiros P, Gariani K, et al.
Cell Syst
. 2018 Jun;
6(6):709-721.e6.
PMID: 29909275
The genetic regulation and physiological impact of most lipid species are unexplored. Here, we profiled 129 plasma lipid species across 49 strains of the BXD mouse genetic reference population fed...