Matthew J P Rush
Overview
Explore the profile of Matthew J P Rush including associated specialties, affiliations and a list of published articles.
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12
Citations
416
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Recent Articles
1.
Rensvold J, Shishkova E, Sverchkov Y, Miller I, Cetinkaya A, Pyle A, et al.
Nature
. 2022 May;
606(7913):382-388.
PMID: 35614220
Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles and have linked their dysfunction to more than...
2.
Rush M, Riley N, Westphall M, Coon J
Anal Chem
. 2018 Jun;
90(15):8946-8953.
PMID: 29949341
Here we report the fragmentation of disulfide linked intact proteins using activated-ion electron transfer dissociation (AI-ETD) for top-down protein characterization. This fragmentation method is then compared to the alternative methods...
3.
Rhoads T, Burhans M, Chen V, Hutchins P, Rush M, Clark J, et al.
Cell Metab
. 2018 Mar;
27(3):677-688.e5.
PMID: 29514073
Caloric restriction (CR) extends lifespan and delays the onset of age-related disorders in diverse species. Metabolic regulatory pathways have been implicated in the mechanisms of CR, but the molecular details...
4.
Veling M, Reidenbach A, Freiberger E, Kwiecien N, Hutchins P, Drahnak M, et al.
Mol Cell
. 2017 Dec;
68(5):970-977.e11.
PMID: 29220658
Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions, although their direct substrates are often difficult to discern. Through multi-omic profiling of diverse Saccharomyces cerevisiae mitoprotease deletion strains,...
5.
Rush M, Riley N, Westphall M, Syka J, Coon J
J Am Soc Mass Spectrom
. 2017 Mar;
28(7):1324-1332.
PMID: 28349437
Negative mode proteome analysis offers access to unique portions of the proteome and several acidic post-translational modifications; however, traditional collision-based fragmentation methods fail to reliably provide sequence information for peptide...
6.
Stefely J, Kwiecien N, Freiberger E, Richards A, Jochem A, Rush M, et al.
Nat Biotechnol
. 2016 Nov;
34(11):1191-1197.
PMID: 27669165
Mitochondrial dysfunction is associated with many human diseases, including cancer and neurodegeneration, that are often linked to proteins and pathways that are not well-characterized. To begin defining the functions of...
7.
Stefely J, Licitra F, Laredj L, Reidenbach A, Kemmerer Z, Grangeray A, et al.
Mol Cell
. 2016 Aug;
63(4):608-620.
PMID: 27499294
The UbiB protein kinase-like (PKL) family is widespread, comprising one-quarter of microbial PKLs and five human homologs, yet its biochemical activities remain obscure. COQ8A (ADCK3) is a mammalian UbiB protein...
8.
Riley N, Rush M, Rose C, Richards A, Kwiecien N, Bailey D, et al.
Mol Cell Proteomics
. 2015 Jul;
14(10):2644-60.
PMID: 26193884
The field of proteomics almost uniformly relies on peptide cation analysis, leading to an underrepresentation of acidic portions of proteomes, including relevant acidic posttranslational modifications. Despite the many benefits negative...
9.
Kwiecien N, Bailey D, Rush M, Cole J, Ulbrich A, Hebert A, et al.
Anal Chem
. 2015 Jul;
87(16):8328-35.
PMID: 26192401
Gas chromatography/mass spectrometry (GC/MS) has long been considered one of the premiere analytical tools for small molecule analysis. Recently, a number of GC/MS systems equipped with high-resolution mass analyzers have...
10.
Rose C, Rush M, Riley N, Merrill A, Kwiecien N, Holden D, et al.
J Am Soc Mass Spectrom
. 2015 Jun;
26(11):1848-57.
PMID: 26111518
Electron transfer dissociation (ETD) has been broadly adopted and is now available on a variety of commercial mass spectrometers. Unlike collisional activation techniques, optimal performance of ETD requires considerable user...