Drug Metabolism and Disposition : the Biological Fate of Chemicals
Overview
Drug Metabolism and Disposition: The Biological Fate of Chemicals is a reputable scientific journal that focuses on the study of how drugs and other chemicals are metabolized and eliminated from the body. It covers a wide range of topics including drug interactions, pharmacokinetics, drug transporters, and drug metabolism pathways. The journal publishes original research articles, reviews, and perspectives, providing valuable insights into the complex processes involved in drug metabolism and disposition.
Details
Details
Abbr.
Drug Metab Dispos
Start
1973
End
Continuing
Frequency
Monthly
p-ISSN
0090-9556
e-ISSN
1521-009X
Country
United States
Language
English
Specialty
Pharmacology
Metrics
Metrics
h-index / Ranks: 772
194
SJR / Ranks: 4213
941
CiteScore / Ranks: 2975
6.90
JIF / Ranks: 2352
3.9
Recent Articles
1.
Heylen S, Nicolai J, Van Asten S, Tuytelaars A, De Wagter K, Snoeys J, et al.
Drug Metab Dispos
. 2025 Mar;
53(3):100045.
PMID: 40086408
To reduce the drug attrition due to failure in clinical trials, an early accurate hepatic clearance (CL) prediction for small molecule drugs is critical. However, the routinely used in vitro...
2.
Yang M, Yao S, Zhang W, Zhao T, Li C, Ai H, et al.
Drug Metab Dispos
. 2025 Mar;
53(4):100049.
PMID: 40073534
HD561, which was designed to enhance nerve growth, was re-engineered into HD56, a carboxylic acid ester prodrug. The goal of this study was to compare the druggability, species differences, and...
3.
Wu X, Ferguson N, Tang L
Drug Metab Dispos
. 2025 Mar;
53(3):100048.
PMID: 40068543
Quantifying proteins involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs is essential to improve understanding of their disposition and pharmacokinetics. Proteomics, because of its great versatility, is...
4.
Farrera D, Alaaldin M, Lindberg P, Sample P, Lenzen-Hammerel P, LaMadrid C, et al.
Drug Metab Dispos
. 2025 Mar;
53(3):100043.
PMID: 40054126
Valsartan (VAL) is commonly prescribed for patients with cardiovascular disease (CVD) to lower blood pressure, reduce heart failure risk, and prevent heart attacks or strokes by blocking the effects of...
5.
Miyake T, Fujita Y, Hirabayashi M, Komiyama N, Morita K, Tachibana T, et al.
Drug Metab Dispos
. 2025 Mar;
53(4):100050.
PMID: 40054035
Drug clearance and drug-drug interactions are essential for pharmacokinetic assessment. However, current in vitro systems and animal scale-up approaches often fail to accurately predict drug disposition mediated by metabolizing enzymes,...
6.
Huang W, Bowman C, Yin M, Han L, Wen Y, Ahn S, et al.
Drug Metab Dispos
. 2025 Mar;
53(3):100042.
PMID: 40048993
The human kidney is a critical organ for the elimination of numerous drugs and metabolites. The mechanisms of renal drug handling are manifold including unbound filtration, transporter-mediated active secretion, bidirectional...
7.
James A, Lanshoeft C, Steeno G, Spracklin D, You Z, Sharma R, et al.
Drug Metab Dispos
. 2025 Mar;
53(3):100041.
PMID: 40048992
The mixed matrix method (MmM) is a widely used approach by the pharmaceutical industry for early assessment of whether exposures to major human circulating metabolites, of traditional small-molecule drugs, are...
8.
Pan H, Zhai G, Jing Q, Fan Y, Fang C, Shi F
Drug Metab Dispos
. 2025 Mar;
53(3):100047.
PMID: 40037093
2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is the most abundant constituent of Polygonum multiflorum and is exclusively found in this herb. This renowned herbal medicine has been documented to lead to liver damage in...
9.
Chen S, Piatkov K, Dong L, Sugimoto H
Drug Metab Dispos
. 2025 Mar;
53(3):100039.
PMID: 40037092
The formation of antidrug antibodies (ADAs) against antibody-drug conjugates (ADCs) can trigger a humoral immune response and change drug exposure. Although the immunogenicity assessment of an ADC drug in nonclinical...
10.
Tsang Y, Rodriguez A, Warren M, Unadkat J
Drug Metab Dispos
. 2025 Mar;
53(3):100046.
PMID: 40024137
Renal clearance of drugs mediated by transporters can be affected by diseases (eg, inflammation due to infections), physiological changes (eg, pregnancy), or drug-drug interactions. To elucidate the transporters involved, the...