Alexander S Hebert
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Explore the profile of Alexander S Hebert including associated specialties, affiliations and a list of published articles.
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67
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2693
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Recent Articles
1.
Peters-Clarke T, Quan Q, Anderson B, McGee W, Lohr E, Hebert A, et al.
Mol Cell Proteomics
. 2024 Feb;
23(4):100742.
PMID: 38401707
Therapeutic RNAs are routinely modified during their synthesis to ensure proper drug uptake, stability, and efficacy. Phosphorothioate (PS) RNA, molecules in which one or more backbone phosphates are modified with...
2.
Khana D, Tatli M, Rivera Vazquez J, Weraduwage S, Stern N, Hebert A, et al.
mSystems
. 2023 Mar;
8(2):e0009223.
PMID: 36995223
Zymomonas mobilis is an industrially relevant aerotolerant anaerobic bacterium that can convert up to 96% of consumed glucose to ethanol. This highly catabolic metabolism could be leveraged to produce isoprenoid-based...
3.
Sinitcyn P, Richards A, Weatheritt R, Brademan D, Marx H, Shishkova E, et al.
Nat Biotechnol
. 2023 Mar;
41(12):1776-1786.
PMID: 36959352
An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically identified by peptide sequences representing a small fraction of their total...
4.
Rensvold J, Shishkova E, Sverchkov Y, Miller I, Cetinkaya A, Pyle A, et al.
Nature
. 2022 May;
606(7913):382-388.
PMID: 35614220
Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles and have linked their dysfunction to more than...
5.
Trujillo E, Hebert A, Rivera Vazquez J, Brademan D, Tatli M, Amador-Noguez D, et al.
Anal Chem
. 2022 Jan;
94(4):1965-1973.
PMID: 35044165
While much effort has been placed on comprehensive quantitative proteome analysis, certain applications demand the measurement of only a few target proteins from complex systems. Traditional approaches to targeted proteomics...
6.
Martien J, Trujillo E, Jacobson T, Tatli M, Hebert A, Stevenson D, et al.
mSystems
. 2021 Nov;
6(6):e0098721.
PMID: 34783580
Zymomonas mobilis is an ethanologenic bacterium currently being developed for production of advanced biofuels. Recent studies have shown that Z. mobilis can fix dinitrogen gas (N) as a sole nitrogen...
7.
Evans A, Hebert A, Mulholland J, Lewis M, Hu P
Anal Chem
. 2021 Jun;
93(26):9166-9173.
PMID: 34161073
Post-translational modifications (PTMs) that impact the safety or efficacy of protein therapeutics are critical quality attributes (CQAs) that need to be controlled to ensure product quality. Peptide mapping with online...
8.
He Y, Rashan E, Linke V, Shishkova E, Hebert A, Jochem A, et al.
Anal Chem
. 2021 Feb;
93(9):4217-4222.
PMID: 33617230
Mass spectrometry (MS) serves as the centerpiece technology for proteome, lipidome, and metabolome analysis. To gain a better understanding of the multifaceted networks of myriad regulatory layers in complex organisms,...
9.
Muehlbauer L, Hebert A, Westphall M, Shishkova E, Coon J
Anal Chem
. 2020 Dec;
92(24):15959-15967.
PMID: 33270415
Mass spectrometry is the premier tool for identifying and quantifying protein phosphorylation on a global scale. Analysis of phosphopeptides requires enrichment, and even after the samples remain highly complex and...
10.
Kurumbang N, Vera J, Hebert A, Coon J, Landick R
PLoS One
. 2020 Aug;
15(8):e0226235.
PMID: 32797046
Plant-derived fuels and chemicals from renewable biomass have significant potential to replace reliance on petroleum and improve global carbon balance. However, plant biomass contains significant fractions of oligosaccharides that are...