Edward Pichinuk
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Explore the profile of Edward Pichinuk including associated specialties, affiliations and a list of published articles.
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20
Citations
199
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Recent Articles
1.
Bigelman E, Pasmanik-Chor M, Dassa B, Itkin M, Malitsky S, Dorot O, et al.
PLoS One
. 2023 Aug;
18(8):e0275550.
PMID: 37616231
Background: Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite whose levels are significantly modified...
2.
Rabinowitz K, Navon M, Edelman-Klapper H, Zittan E, Bar-Gil Shitrit A, Goren I, et al.
Vaccines (Basel)
. 2022 Jul;
10(8).
PMID: 35893835
Patients with inflammatory bowel disease (IBD) treated with anti-tumor-necrosis factor-alpha (TNFα) exhibited lower serologic responses one-month following the second dose of the COVID-19 BNT162b2 vaccine compared to those not treated...
3.
Dorot O, Roux L, Zennaro L, Oved K, Bremond-Gignac D, Pichinuk E, et al.
Ocul Surf
. 2021 Dec;
23:140-142.
PMID: 34890804
Aniridia is a panocular disease causing progressive severe visual impairment and blindness due to PAX-6 haploinsufficiency. One of the most disabling ocular symptoms is aniridia-related keratopathy (ARK), a progressive corneal...
4.
Oved K, Zennaro L, Dorot O, Zerbib J, Frank E, Roux L, et al.
Biochem Biophys Res Commun
. 2021 Oct;
582:100-104.
PMID: 34700241
Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function....
5.
Morein D, Rubinstein-Achiasaf L, Brayer H, Dorot O, Pichinuk E, Ben-Yaakov H, et al.
Cells
. 2021 Jun;
10(6).
PMID: 34072893
Chronic inflammation promotes cancer progression by affecting the tumor cells and their microenvironment. Here, we demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the...
6.
Rubinstein-Achiasaf L, Morein D, Ben-Yaakov H, Liubomirski Y, Meshel T, Elbaz E, et al.
Cancers (Basel)
. 2021 Apr;
13(6).
PMID: 33806906
The pro-inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β) are expressed simultaneously and have tumor-promoting roles in breast cancer. In parallel, mesenchymal stem cells (MSCs) undergo conversion...
7.
Pichinuk E, Chalik M, Benhar I, Ginat-Koton R, Ziv R, Smorodinsky N, et al.
Cancer Immunol Immunother
. 2020 Mar;
69(7):1337-1352.
PMID: 32219500
Cleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed against the MUC1 alpha-beta junction comprising the SEA domain,...
8.
Viswanathan G, Shwartz D, Losev Y, Arad E, Shemesh C, Pichinuk E, et al.
Cell Mol Life Sci
. 2019 Sep;
77(14):2795-2813.
PMID: 31562564
Neurofibrillary tangles of the Tau protein and plaques of the amyloid β peptide are hallmarks of Alzheimer's disease (AD), which is characterized by the conversion of monomeric proteins/peptides into misfolded...
9.
Elias R, Benhamou R, Jaber Q, Dorot O, Zada S, Oved K, et al.
Eur J Med Chem
. 2019 Jul;
179:779-790.
PMID: 31288127
Azole antifungals inhibit the biosynthesis of ergosterol, the fungal equivalent of cholesterol in mammalian cells. Here we report an investigation of the activity of coumarin-substituted azole antifungals. Screening against a...
10.
Laor D, Sade D, Shaham-Niv S, Zaguri D, Gartner M, Basavalingappa V, et al.
Nat Commun
. 2019 Jan;
10(1):62.
PMID: 30622276
The extension of the amyloid hypothesis to include non-protein metabolite assemblies invokes a paradigm for the pathology of inborn error of metabolism disorders. However, a direct demonstration of the assembly...