Avi Raveh
Overview
Explore the profile of Avi Raveh including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
209
Followers
0
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Recent Articles
1.
Burg S, Shapiro S, Peretz A, Haimov E, Redko B, Yeheskel A, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(34):e2202926119.
PMID: 35969786
The Ca-activated SK4 K channel is gated by Ca-calmodulin (CaM) and is expressed in immune cells, brain, and heart. A cryoelectron microscopy (cryo-EM) structure of the human SK4 K channel...
2.
Viswanathan G, Shwartz D, Losev Y, Arad E, Shemesh C, Pichinuk E, et al.
Cell Mol Life Sci
. 2019 Sep;
77(14):2795-2813.
PMID: 31562564
Neurofibrillary tangles of the Tau protein and plaques of the amyloid β peptide are hallmarks of Alzheimer's disease (AD), which is characterized by the conversion of monomeric proteins/peptides into misfolded...
3.
Laor D, Sade D, Shaham-Niv S, Zaguri D, Gartner M, Basavalingappa V, et al.
Nat Commun
. 2019 Jan;
10(1):62.
PMID: 30622276
The extension of the amyloid hypothesis to include non-protein metabolite assemblies invokes a paradigm for the pathology of inborn error of metabolism disorders. However, a direct demonstration of the assembly...
4.
Haj E, Losev Y, Krishnakumar V, Pichinuk E, Engel H, Raveh A, et al.
Biochim Biophys Acta Gen Subj
. 2018 Apr;
1862(7):1565-1575.
PMID: 29634991
Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (Aβ) peptides in the human brain. Understanding...
5.
Li S, Lowell A, Yu F, Raveh A, Newmister S, Bair N, et al.
J Am Chem Soc
. 2015 Dec;
137(49):15366-9.
PMID: 26629885
Hapalindoles are bioactive indole alkaloids with fascinating polycyclic ring systems whose biosynthetic assembly mechanism has remained unknown since their initial discovery in the 1980s. In this study, we describe the...
6.
Cheng K, Cao S, Raveh A, Macarthur R, Dranchak P, Chlipala G, et al.
J Nat Prod
. 2015 Oct;
78(10):2411-22.
PMID: 26465675
Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can therefore...
7.
Delekta P, Raveh A, Larsen M, Schultz P, Tamayo-Castillo G, Sherman D, et al.
J Biomol Screen
. 2015 Jan;
20(5):673-80.
PMID: 25550354
Alphaviruses are a prominent class of reemergent pathogens due to their globally expanding ranges, potential for lethality, and possible use as bioweapons. The absence of effective treatments for alphaviruses highlights...
8.
Raveh A, Schultz P, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, et al.
Mol Pharmacol
. 2014 Aug;
86(4):406-16.
PMID: 25086086
Biochemical high-throughput screening is widely used in drug discovery, using a variety of small molecule libraries. However, broader screening strategies may be more beneficial to identify novel biologic mechanisms. In...
9.
Walter G, Raveh A, Mok S, McQuade T, Arevang C, Schultz P, et al.
Chem Biol Drug Des
. 2014 Mar;
83(4):440-9.
PMID: 24636344
Proteins with expanded polyglutamine (polyQ) segments cause a number of fatal neurodegenerative disorders, including Huntington's disease (HD). Previous high-throughput screens in cellular and biochemical models of HD have revealed compounds...
10.
Raveh A, Delekta P, Dobry C, Peng W, Schultz P, Blakely P, et al.
PLoS One
. 2013 Dec;
8(12):e82318.
PMID: 24349254
Natural products provide a vast array of chemical structures to explore in the discovery of new medicines. Although secondary metabolites produced by microbes have been developed to treat a variety...