Daniel H Wreschner
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Explore the profile of Daniel H Wreschner including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Kiyozumi D, Shimada K, Chalick M, Emori C, Kodani M, Oura S, et al.
Nat Commun
. 2023 Apr;
14(1):2354.
PMID: 37095084
The mammalian spermatozoa produced in the testis require functional maturation in the epididymis for their full competence. Epididymal sperm maturation is regulated by lumicrine signalling pathways in which testis-derived secreted...
2.
Shmerling M, Chalik M, Smorodinsky N, Meeker A, Roy S, Sagi-Assif O, et al.
Immunohorizons
. 2022 Apr;
6(4):253-272.
PMID: 35440514
Syntenic genomic loci on human chromosome 8 and mouse chromosome 15 (mChr15) code for LY6/Ly6 (lymphocyte Ag 6) family proteins. The 23 murine family genes include eight genes that are...
3.
Pichinuk E, Chalik M, Benhar I, Ginat-Koton R, Ziv R, Smorodinsky N, et al.
Cancer Immunol Immunother
. 2020 Mar;
69(7):1337-1352.
PMID: 32219500
Cleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed against the MUC1 alpha-beta junction comprising the SEA domain,...
4.
Guillaume T, Dehame V, Chevallier P, Peterlin P, Garnier A, Gregoire M, et al.
Exp Hematol
. 2018 Dec;
70:97-108.
PMID: 30593830
Cell surface molecules aberrantly expressed or overexpressed by myeloid leukemic cells represent potential disease-specific therapeutic targets for antibodies. MUC1 is a polymorphic glycoprotein, the cleavage of which yields two unequal...
5.
Chalick M, Jacobi O, Pichinuk E, Garbar C, Bensussan A, Meeker A, et al.
PLoS One
. 2016 Oct;
11(10):e0165031.
PMID: 27768738
Translation of mRNA in alternate reading frames (ARF) is a naturally occurring process heretofore underappreciated as a generator of protein diversity. The MUC1 gene encodes MUC1-TM, a signal-transducing trans-membrane protein...
6.
Lees C, Smorodinsky N, Horn G, Wreschner D, McKenzie I, Pietersz G, et al.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
. 2016 Jul;
37(1):15-25.
PMID: 27442413
Immunotherapy using mucin 1 (MUC1) linked to oxidised mannan (MFP) was investigated in an aggressive MUC1+ metastatic tumour, DA3-MUC1 because, unlike many MUC1+ tumour models, DA3-MUC1 is not spontaneously rejected...
7.
Pichinuk E, Benhar I, Jacobi O, Chalik M, Weiss L, Ziv R, et al.
Cancer Res
. 2012 Apr;
72(13):3324-36.
PMID: 22507854
The cell-surface glycoprotein MUC1 is a particularly appealing target for antibody targeting, being selectively overexpressed in many types of cancers and a high proportion of cancer stem-like cells. However the...
8.
Pichinuk E, Broday L, Wreschner D
Biochem Biophys Res Commun
. 2011 Oct;
414(4):706-11.
PMID: 22001924
We previously suggested a mechanism whereby the RNA induced silencing complex (RISC) brings about a specific cleavage at the sarcin-ricin loop (SRL) of 28S ribosomal RNA thereby eliciting translational suppression....
9.
Zaretsky J, Wreschner D
Transl Oncogenomics
. 2011 May;
3:99-136.
PMID: 21566747
In the review, the nature of protein multifunctionality is analyzed. In the first part of the review the principles of structural/functional organization of protein are discussed. In the second part,...
10.
Pichinuk E, Wreschner D
Protein Sci
. 2010 Jun;
19(6):1272-8.
PMID: 20512980
We report structural, functional, and biochemical similarities between Argonautes, the effector proteins of RNA-induced silencing complexes (RISCs), and alpha-sarcin-like ribotoxins. At the structural level, regions of similarity in the amino...