David W Speicher
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Explore the profile of David W Speicher including associated specialties, affiliations and a list of published articles.
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177
Citations
8229
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Recent Articles
1.
Lipchick B, Guterres A, Chen H, Zundell D, Del Aguila S, Reyes-Uribe P, et al.
Sci Transl Med
. 2025 Feb;
17(784):eadp8913.
PMID: 39908352
Although oncogenic NRAS activates mitogen-activated protein kinase (MAPK) signaling, inhibition of the MAPK pathway is not therapeutically efficacious in -mutant () tumors. Here, we report that selectively silencing the ribosomal...
2.
Fane M, Chhabra Y, Alicea G, Maranto D, Douglass S, Webster M, et al.
Nature
. 2025 Jan;
638(8051):E31.
PMID: 39890900
No abstract available.
3.
Alicea G, Patel P, Portuallo M, Fane M, Wei M, Chhabra Y, et al.
Cancer Res Commun
. 2024 Jul;
4(8):1908-1918.
PMID: 39007351
Significance: The aged microenvironment drives metastasis in melanoma cells. This study reports that IGFBP2 secretion by aged fibroblasts induces lipid accumulation in melanoma cells, driving an increase in tumor invasiveness....
4.
Barnhart K, Bollig K, Senapati S, Takacs P, Robins J, Haisenleder D, et al.
Fertil Steril
. 2024 Apr;
122(3):482-493.
PMID: 38677710
Objective: To evaluate combinations of candidate biomarkers to develop a multiplexed prediction model for identifying the viability and location of an early pregnancy. In this study, we assessed 24 biomarkers...
5.
Hao X, Zhao B, Towers M, Liao L, Monteiro E, Xu X, et al.
Nat Aging
. 2024 Jan;
4(2):185-197.
PMID: 38267705
Sterile inflammation, also known as 'inflammaging', is a hallmark of tissue aging. Cellular senescence contributes to tissue aging, in part, through the secretion of proinflammatory factors collectively known as the...
6.
Bollig K, Senapati S, Takacs P, Robins J, Haisenleder D, Beer L, et al.
Biol Reprod
. 2023 Nov;
110(3):548-557.
PMID: 38011676
Objective: To assess performance and discriminatory capacity of commercially available enzyme-linked immunosorbent assays of biomarkers for predicting first trimester pregnancy outcome in a multi-center cohort. Design: In a case-control study...
7.
Beer L, Yin X, Ding J, Senapati S, Sammel M, Barnhart K, et al.
Clin Proteomics
. 2023 Sep;
20(1):37.
PMID: 37715129
Background: Differentiating between a normal intrauterine pregnancy (IUP) and abnormal conditions including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical challenge in early pregnancy. Currently, serial...
8.
Dheekollu J, Wiedmer A, Soldan S, Castro-Munoz L, Chen C, Tang H, et al.
PLoS Pathog
. 2023 Jun;
19(6):e1010478.
PMID: 37262099
Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that is causally associated with various malignancies and autoimmune disease. Epstein-Barr Nuclear Antigen 1 (EBNA1) is the viral-encoded DNA binding protein required...
9.
Yeon M, Bertolini I, Agarwal E, Ghosh J, Tang H, Speicher D, et al.
J Biol Chem
. 2023 May;
299(6):104774.
PMID: 37142218
Mitochondria are signaling organelles implicated in cancer, but the mechanisms are elusive. Here, we show that Parkin, an E3 ubiquitination (Ub) ligase altered in Parkinson's disease, forms a complex with...
10.
Bhardwaj M, Lee J, Versace A, Harper S, Goldman A, Crissey M, et al.
J Clin Invest
. 2023 Feb;
133(8).
PMID: 36795483
Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as DC661 can produce cell death, but the mechanism for this is not completely understood. Programmed cell death pathways (autophagy,...