David W Speicher
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Explore the profile of David W Speicher including associated specialties, affiliations and a list of published articles.
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177
Citations
8229
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Recent Articles
11.
Jain V, Harper S, Versace A, Fingerman D, Brown G, Bhardwaj M, et al.
Cancer Discov
. 2022 Nov;
13(2):454-473.
PMID: 36331284
Significance: We discovered UGCG-dependent lipid remodeling drives resistance to LAI. Targeting UGCG with a drug approved for a lysosomal storage disorder enhanced LAI antitumor activity without toxicity. LAI and UGCG...
12.
Sharma G, Ojha R, Noguera-Ortega E, Rebecca V, Attanasio J, Liu S, et al.
JCI Insight
. 2022 Oct;
7(20).
PMID: 36278493
No abstract available.
13.
Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, et al.
Cell Rep
. 2022 Oct;
41(3):111514.
PMID: 36261012
We identify ADIRF-AS1 circadian long non-coding RNA (lncRNA). Deletion of ADIRF-AS1 in U2OS cells alters rhythmicity of clock-controlled genes and expression of extracellular matrix genes. ADIRF-AS1 interacts with all components...
14.
Tcyganov E, Sanseviero E, Marvel D, Beer T, Tang H, Hembach P, et al.
Cancer Cell
. 2022 Oct;
40(10):1173-1189.e6.
PMID: 36220073
Cancer immunotherapy often depends on recognition of peptide epitopes by cytotoxic T lymphocytes (CTLs). The tumor microenvironment (TME) is enriched for peroxynitrite (PNT), a potent oxidant produced by infiltrating myeloid...
15.
Guan L, Wu B, Li T, Beer L, Sharma G, Li M, et al.
Nat Commun
. 2022 Jul;
13(1):4078.
PMID: 35835783
The lack of tumor infiltration by CD8 T cells is associated with poor patient response to anti-PD-1 therapy. Understanding how tumor infiltration is regulated is key to improving treatment efficacy....
16.
Fane M, Chhabra Y, Alicea G, Maranto D, Douglass S, Webster M, et al.
Nature
. 2022 Jun;
606(7913):396-405.
PMID: 35650435
Disseminated cancer cells from primary tumours can seed in distal tissues, but may take several years to form overt metastases, a phenomenon that is termed tumour dormancy. Despite its importance...
17.
Vedula P, Tang H, Speicher D, Kashina A
Front Cell Dev Biol
. 2022 Feb;
10:807149.
PMID: 35223838
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has...
18.
Beer L, Senapati S, Sammel M, Barnhart K, Schreiber C, Speicher D
Reprod Biol Endocrinol
. 2022 Feb;
20(1):36.
PMID: 35189928
Background: In early pregnancy, differentiating between a normal intrauterine pregnancy (IUP) and abnormal gestations including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical challenge when ultrasound...
19.
Ghosh J, Perego M, Agarwal E, Bertolini I, Wang Y, Goldman A, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(8).
PMID: 35177476
Cancer metabolism, including in mitochondria, is a disease hallmark and therapeutic target, but its regulation is poorly understood. Here, we show that many human tumors have heterogeneous and often reduced...
20.
Han A, Chua V, Baqai U, Purwin T, Bechtel N, Hunter E, et al.
Oncogene
. 2022 Jan;
41(8):1129-1139.
PMID: 35046531
Effective therapeutic options are still lacking for uveal melanoma (UM) patients who develop metastasis. Metastatic traits of UM are linked to BRCA1-associated protein 1 (BAP1) mutations. Cell metabolism is re-programmed...