Sandra L Harper
Overview
Explore the profile of Sandra L Harper including associated specialties, affiliations and a list of published articles.
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16
Citations
233
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Recent Articles
1.
Bhardwaj M, Lee J, Versace A, Harper S, Goldman A, Crissey M, et al.
J Clin Invest
. 2023 Feb;
133(8).
PMID: 36795483
Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as DC661 can produce cell death, but the mechanism for this is not completely understood. Programmed cell death pathways (autophagy,...
2.
Jain V, Harper S, Versace A, Fingerman D, Brown G, Bhardwaj M, et al.
Cancer Discov
. 2022 Nov;
13(2):454-473.
PMID: 36331284
Significance: We discovered UGCG-dependent lipid remodeling drives resistance to LAI. Targeting UGCG with a drug approved for a lysosomal storage disorder enhanced LAI antitumor activity without toxicity. LAI and UGCG...
3.
Sharma G, Ojha R, Noguera-Ortega E, Rebecca V, Attanasio J, Liu S, et al.
JCI Insight
. 2022 Oct;
7(20).
PMID: 36278493
No abstract available.
4.
Sharma G, Ojha R, Noguera-Ortega E, Rebecca V, Attanasio J, Liu S, et al.
JCI Insight
. 2020 Aug;
5(17).
PMID: 32780726
New strategies are needed to enhance the efficacy of anti-programmed cell death protein antibody (anti-PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of...
5.
Singha B, Harper S, Goldman A, Bitler B, Aird K, Borowsky M, et al.
Sci Rep
. 2018 Oct;
8(1):14725.
PMID: 30282979
New plasma and tissue biomarkers of epithelial ovarian cancer (EOC) could improve early diagnosis and post-diagnosis clinical management. Here we investigated tissue staining and tissue secretion of CLIC1 and CLIC4...
6.
Rivera-Santiago R, Harper S, Sriswasdi S, Hembach P, Speicher D
Structure
. 2016 Dec;
25(1):132-145.
PMID: 27989623
Anion exchanger 1 (AE1) is a critical transporter and the primary structural scaffold for large macromolecular complexes responsible for erythrocyte membrane flexibility and integrity. We used zero-length crosslinking and mass...
7.
Rivera-Santiago R, Sriswasdi S, Harper S, Speicher D
Methods
. 2015 May;
89:99-111.
PMID: 25937394
Structural mass spectrometry (MS) is a field with growing applicability for addressing complex biophysical questions regarding proteins and protein complexes. One of the major structural MS approaches involves the use...
8.
Rivera-Santiago R, Harper S, Zhou S, Sriswasdi S, Feinstein S, Fisher A, et al.
Biochem J
. 2015 Mar;
468(1):87-98.
PMID: 25748205
Peroxiredoxin-6 (PRDX6) is an unusual member of the peroxiredoxin family of antioxidant enzymes that has only one evolutionarily conserved cysteine. It reduces oxidized lipids and reactive oxygen species (ROS) by...
9.
Khanna M, Mattie F, Browder K, Radyk M, Crilly S, Bakerink K, et al.
J Biol Chem
. 2014 Nov;
290(2):706-15.
PMID: 25381248
The dominant paradigm for spectrin function is that (αβ)2-spectrin tetramers or higher order oligomers form membrane-associated two-dimensional networks in association with F-actin to reinforce the plasma membrane. Tetramerization is an...
10.
Sriswasdi S, Harper S, Tang H, Gallagher P, Speicher D
Proc Natl Acad Sci U S A
. 2014 Jan;
111(5):1801-6.
PMID: 24453214
Conformational changes of macromolecular complexes play key mechanistic roles in many biological processes, but large, highly flexible proteins and protein complexes usually cannot be analyzed by crystallography or NMR. Here,...