David L Smiley
Overview
Explore the profile of David L Smiley including associated specialties, affiliations and a list of published articles.
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15
Citations
777
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Recent Articles
1.
Hoover S, Perez A, Tsui H, Sinha D, Smiley D, DiMarchi R, et al.
Mol Microbiol
. 2015 Apr;
97(2):229-43.
PMID: 25869931
The Phr peptides of the Bacillus species mediate quorum sensing, but their identification and function in other species of bacteria have not been determined. We have identified a Phr peptide...
2.
Finan B, Yang B, Ottaway N, Smiley D, Ma T, Clemmensen C, et al.
Nat Med
. 2014 Dec;
21(1):27-36.
PMID: 25485909
We report the discovery of a new monomeric peptide that reduces body weight and diabetic complications in rodent models of obesity by acting as an agonist at three key metabolically-related...
3.
Finan B, Ma T, Ottaway N, Muller T, Habegger K, Heppner K, et al.
Sci Transl Med
. 2013 Nov;
5(209):209ra151.
PMID: 24174327
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic...
4.
Heppner K, Piechowski C, Muller A, Ottaway N, Sisley S, Smiley D, et al.
Diabetes
. 2013 Sep;
63(1):122-31.
PMID: 24062249
Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that des-AG (dAG) has biological activity through GHSR-independent...
5.
Kuna R, Girada S, Asalla S, Vallentyne J, Maddika S, Patterson J, et al.
Am J Physiol Endocrinol Metab
. 2013 Apr;
305(2):E161-70.
PMID: 23592482
Glucagon-like peptide-1 receptor (GLP-1R) plays a major role in promoting glucose-stimulated insulin secretion in pancreatic β-cells. In the present study, we synthesized a novel functional analog of GLP-1 conjugated to...
6.
Heppner K, Chaudhary N, Muller T, Kirchner H, Habegger K, Ottaway N, et al.
Endocrinology
. 2012 Aug;
153(10):4687-95.
PMID: 22865372
Ghrelin is a gastrointestinal polypeptide that acts through the ghrelin receptor (GHSR) to promote food intake and increase adiposity. Activation of GHSR requires the presence of a fatty-acid (FA) side...
7.
Perez-Tilve D, Heppner K, Kirchner H, Lockie S, Woods S, Smiley D, et al.
FASEB J
. 2011 May;
25(8):2814-22.
PMID: 21543764
Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive energy balance by increasing food...
8.
Patterson J, Ottaway N, Gelfanov V, Smiley D, Perez-Tilve D, Pfluger P, et al.
ACS Chem Biol
. 2010 Oct;
6(2):135-45.
PMID: 20939591
Ex-4 (9-39)a is a well characterized GLP-1 receptor antagonist that suffers from two notable limitations, its nonhuman amino acid sequence and its relatively short in vivo duration of action. Comparable...
9.
Hsiung H, Hertel J, Zhang X, Smith D, Smiley D, Heiman M, et al.
Endocrinology
. 2005 Sep;
146(12):5257-66.
PMID: 16166226
alphaMSH has generally been accepted as the endogenous ligand for melanocortin 4 receptor (MC4R), which plays a major role in energy homeostasis. Targeting MC4R to develop antiobesity agents, many investigators...
10.
Yan L, Flora D, Edwards P, Smiley D, Emmerson P, Hsiung H, et al.
Bioorg Med Chem Lett
. 2005 Aug;
15(20):4611-4.
PMID: 16105738
Extensive structure-activity relationship studies utilizing a beta-MSH-derived cyclic nonapeptide, Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (3), led to identification of a series of novel MC-4R selective disulfide-constrained hexapeptide analogs including Ac-[hCys-His-D-Phe-Arg-Trp-Cys]-NH(2) (12). The structural modifications...