Paul T Pfluger
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Explore the profile of Paul T Pfluger including associated specialties, affiliations and a list of published articles.
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104
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Recent Articles
1.
Bernecker M, Lin A, Feuchtinger A, Molenaar A, Schriever S, Pfluger P
J Transl Med
. 2025 Jan;
23(1):7.
PMID: 39754229
Background: Obese subjects undergoing weight loss often fear the Yoyo dieting effect, which involves regaining or even surpassing their initial weight. To date, our understanding of such long-term obesity and...
2.
Contreras R, Gruber T, Gonzalez-Garcia I, Schriever S, De Angelis M, Mallet N, et al.
Mol Metab
. 2024 Sep;
90:102033.
PMID: 39304061
With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary lifestyle and high calorie intake, genetic and epigenetic factors also play...
3.
Decoster L, Trova S, Zucca S, Bulk J, Gouveia A, Ternier G, et al.
Nat Neurosci
. 2024 Aug;
27(9):1758-1773.
PMID: 39095587
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons regulate fertility and integrate hormonal status with environmental cues to ensure reproductive success. Here we show that GnRH neurons in the olfactory bulb (GnRH) of...
4.
Correa-da-Silva F, Carter J, Wang X, Sun R, Pathak E, Kuhn J, et al.
Acta Neuropathol
. 2024 Mar;
147(1):64.
PMID: 38556574
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of cases. Two distinct genetic subtypes of...
5.
Akindehin S, Liskiewicz A, Liskiewicz D, Bernecker M, Garcia-Caceres C, Drucker D, et al.
Mol Metab
. 2024 Mar;
83:101915.
PMID: 38492844
Objective: The glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) signaling, but the underlying mechanisms remain largely unknown. Here, we assessed whether GIP regulates body weight...
6.
Gruber T, Lechner F, Murat C, Contreras R, Sanchez-Quant E, Miok V, et al.
Cell Rep
. 2023 Oct;
42(10):113305.
PMID: 37864798
Oxytocin-expressing paraventricular hypothalamic neurons (PVN neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVN neurons orchestrate gut-to-brain...
7.
Gonzalez-Garcia I, Garcia-Clave E, Cebrian-Serrano A, Le Thuc O, Contreras R, Xu Y, et al.
Cell Metab
. 2023 Mar;
35(3):438-455.e7.
PMID: 36889283
Until menopause, women have a lower propensity to develop metabolic diseases than men, suggestive of a protective role for sex hormones. Although a functional synergy between central actions of estrogens...
8.
Kulaj K, Harger A, Bauer M, Caliskan O, Gupta T, Chiang D, et al.
Nat Commun
. 2023 Feb;
14(1):709.
PMID: 36759608
Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, to delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing...
9.
Maity-Kumar G, Stander L, DeAngelis M, Lee S, Molenaar A, Becker L, et al.
Mol Metab
. 2022 Oct;
66:101616.
PMID: 36270613
Objective: The Allan-Herndon-Dudley syndrome (AHDS) is a severe disease caused by dysfunctional central thyroid hormone transport due to functional loss of the monocarboxylate transporter 8 (MCT8). In this study, we...
10.
De Angelis M, Maity-Kumar G, Schriever S, Kozlova E, Muller T, Pfluger P, et al.
J Pharm Biomed Anal
. 2022 Sep;
221:115038.
PMID: 36152487
The Allan-Herndon Dudley Syndrome (AHDS) is a rare disease caused by the progressive loss of monocarboxylate transporter 8 (MCT8). In patients with AHDS, the absence of MCT8 impairs transport of...