David J Izon
Overview
Explore the profile of David J Izon including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
855
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Recent Articles
1.
Smeets M, DeLuca E, Wall M, Quach J, Chalk A, Deans A, et al.
J Clin Invest
. 2014 Jun;
124(8):3551-65.
PMID: 24960165
Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive cancer-predisposition disorder Rothmund-Thomson syndrome, though it is unclear how these mutations lead to disease. Here, we demonstrated...
2.
Smeets M, Wiest D, Izon D
Eur J Immunol
. 2014 Jun;
44(9):2617-24.
PMID: 24935715
Friend leukemia integration 1 (Fli-1) is a member of the Ets transcription factor family and is expressed during T-cell development; however, the role Fli-1 plays in early T-cell differentiation has...
3.
Smeets M, Mackenzie-Kludas C, Mohtashami M, Zhang H, Zuniga-Pflucker J, Izon D
Int Immunol
. 2013 Aug;
25(10):589-99.
PMID: 23988615
The majority of T-cell development occurs in the thymus. Thymic epithelial cells are specialized cells that express NOTCH ligands and secrete specific cytokines required for normal T-cell lymphopoiesis. It has...
4.
Smeets M, Chan A, Dagger S, Bradley C, Wei A, Izon D
PLoS One
. 2013 May;
8(5):e62346.
PMID: 23667468
The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but the role of Fli-1 in T cell development has not been closely...
5.
Jurado S, Gleeson K, ODonnell K, Izon D, Walkley C, Strasser A, et al.
J Exp Med
. 2012 Aug;
209(9):1629-39.
PMID: 22891272
Developing B lymphocytes expressing defective or autoreactive pre-B or B cell receptors (BCRs) are eliminated by programmed cell death, but how the balance between death and survival signals is regulated...
6.
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Glaser S, Lee E, Trounson E, Bouillet P, Wei A, Fairlie W, et al.
Genes Dev
. 2012 Jan;
26(2):120-5.
PMID: 22279045
Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-x(L) and Mcl-1. Here we...
7.
Walkley C, Izon D, Purton L
Cell Stem Cell
. 2011 Jun;
8(6):602-3.
PMID: 21624800
The Notch signaling pathway is activated in the majority of T cell acute lymphoblastic leukemias (T-ALL). Adding to the complexity of Notch signaling in hematopoiesis, recently in Nature, Klinakis et...
8.
Singbrant S, Russell M, Jovic T, Liddicoat B, Izon D, Purton L, et al.
Blood
. 2011 Mar;
117(21):5631-42.
PMID: 21421837
Erythropoietin (Epo) has been used in the treatment of anemia resulting from numerous etiologies, including renal disease and cancer. However, its effects are controversial and the expression pattern of the...
9.
Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, et al.
J Immunol
. 2010 Jun;
185(1):367-75.
PMID: 20530266
Asymmetric cell division is a potential means by which cell fate choices during an immune response are orchestrated. Defining the molecular mechanisms that underlie asymmetric division of T cells is...
10.