Warren S Pear
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Explore the profile of Warren S Pear including associated specialties, affiliations and a list of published articles.
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127
Citations
8128
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Recent Articles
1.
McClory S, Bardhan O, Rome K, Giles J, Baxter A, Xu L, et al.
Cell Rep
. 2023 Aug;
42(8):112905.
PMID: 37527035
CD8 T cell exhaustion (T) impairs the ability of T cells to clear chronic infection or cancer. While T are hypofunctional, some T retain effector gene signatures, a feature associated...
2.
McClory S, Bardhan O, Rome K, Giles J, Baxter A, Xu L, et al.
bioRxiv
. 2023 Feb;
PMID: 36824931
T cell exhaustion (T ) impairs the ability of T cells to clear chronic infection or cancer. While exhausted T cells are hypofunctional, some exhausted T cells retain effector gene...
3.
Li T, Bou-Dargham M, Fultang N, Li X, Pear W, Sun H, et al.
J Leukoc Biol
. 2022 Jun;
112(4):845-859.
PMID: 35694784
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of leukocytes that are important for tumorigenesis and tumor immunotherapy. They comprise up to 10% of leukocytes in the blood of tumor...
4.
Gomez Atria D, Gaudette B, Londregan J, Kelly S, Perkey E, Allman A, et al.
J Clin Invest
. 2022 May;
132(13).
PMID: 35579963
In lymphopenic environments, secondary lymphoid organs regulate the size of B and T cell compartments by supporting the homeostatic proliferation of mature lymphocytes. The molecular mechanisms underlying these responses and...
5.
6.
Zhou Y, Petrovic J, Zhao J, Zhang W, Bigdeli A, Zhang Z, et al.
Mol Cell
. 2022 Feb;
82(5):1003-1020.e15.
PMID: 35182476
Chromatin misfolding has been implicated in cancer pathogenesis; yet, its role in therapy resistance remains unclear. Here, we systematically integrated sequencing and imaging data to examine the spatial and linear...
7.
Schwartz G, Zhou Y, Petrovic J, Pear W, Faryabi R
Cell Rep
. 2021 Aug;
36(8):109575.
PMID: 34433064
Emerging single-cell epigenomic assays are used to investigate the heterogeneity of chromatin activity and its function. However, identifying cells with distinct regulatory elements and clearly visualizing their relationships remains challenging....
8.
Kobia F, Preusse K, Dai Q, Weaver N, Hass M, Chaturvedi P, et al.
PLoS Biol
. 2020 Oct;
18(10):e3000850.
PMID: 33017398
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor...
9.
Rome K, Stein S, Kurachi M, Petrovic J, Schwartz G, Mack E, et al.
J Exp Med
. 2020 Mar;
217(5).
PMID: 32150623
In chronic infections, the immune response fails to control virus, leading to persistent antigen stimulation and the progressive development of T cell exhaustion. T cell effector differentiation is poorly understood...
10.
Schwartz G, Zhou Y, Petrovic J, Fasolino M, Xu L, Shaffer S, et al.
Nat Methods
. 2020 Mar;
17(4):405-413.
PMID: 32123397
Identifying and visualizing transcriptionally similar cells is instrumental for accurate exploration of the cellular diversity revealed by single-cell transcriptomics. However, widely used clustering and visualization algorithms produce a fixed number...