David J Izon
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Explore the profile of David J Izon including associated specialties, affiliations and a list of published articles.
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23
Citations
855
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Recent Articles
11.
Croom H, Izon D, Chong M, Curtis D, Roberts A, Kay T, et al.
Mol Immunol
. 2008 Mar;
45(10):2888-96.
PMID: 18321577
Cytokine signals are central to the differentiation of thymocytes and their stepwise progression through defined developmental stages. The intensity and duration of cytokine signals are regulated by the suppressor of...
12.
Rice K, Izon D, Ford J, Boodhoo A, Kees U, Greene W
Leuk Res
. 2007 Dec;
32(6):873-83.
PMID: 18082256
TLX1/HOX11 is an oncogenic transcription factor in human T-cell leukemia, however, the molecular basis for its transforming activity has remained elusive. The ALDH1A1 gene, whose product participates in retinoic acid...
13.
Michie A, Chan A, Ciofani M, Carleton M, Lefebvre J, He Y, et al.
Int Immunol
. 2007 Nov;
19(12):1421-30.
PMID: 17981791
Notch1 signalling is essential for the commitment of multipotent lymphocyte precursors towards the alphabeta T-cell lineage and plays an important role in regulating beta-selection in CD4(-)CD8(-) double-negative (DN) thymocytes. However,...
14.
Chan A, Smeets M, Izon D
Mol Immunol
. 2007 Sep;
45(3):682-9.
PMID: 17826832
Functional genetic screens on mutant backgrounds have been successfully used in lower organisms to investigate biological processes. However, few identical screens have been performed in mice. Recombinase activating gene-1 deficient...
15.
Gothert J, Brake R, Smeets M, Duhrsen U, Begley C, Izon D
Blood
. 2007 Aug;
110(10):3753-62.
PMID: 17698635
The acquired activation of stem cell leukemia (SCL) during T lymphopoiesis is a common event in T-cell acute lymphoblastic leukemia (T-ALL). Here, we generated tamoxifen (TAM)-inducible transgenic mice (lck-ER(T2)-SCL) to...
16.
Dixon D, Izon D, Dagger S, Callow M, Taplin R, Kees U, et al.
Br J Haematol
. 2007 Jun;
138(1):54-67.
PMID: 17555447
The TLX/HOX11 subfamily of divergent homeobox genes are involved in various aspects of embryogenesis and, in the case of TLX1/HOX11 and TLX3/HOX11L2, feature prominently as oncogenes in human T-cell acute...
17.
Glaser S, Metcalf D, Wu L, Hart A, DiRago L, Mifsud S, et al.
Proc Natl Acad Sci U S A
. 2006 Oct;
103(44):16460-5.
PMID: 17060613
Mixl1, the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendodermal structures during early embryogenesis. Gene targeting and overexpression...
18.
Gothert J, Gustin S, Hall M, Green A, Gottgens B, Izon D, et al.
Blood
. 2004 Dec;
105(7):2724-32.
PMID: 15598809
Evidence for the lineage relationship between embryonic and adult hematopoietic stem cells (HSCs) in the mouse is primarily indirect. In order to study this relationship in a direct manner, we...
19.
Gothert J, Gustin S, van Eekelen J, Schmidt U, Hall M, Jane S, et al.
Blood
. 2004 Jun;
104(6):1769-77.
PMID: 15187022
Tumor growth is dependent in part on "neoangiogenesis." Functional involvement of bone marrow (BM)-derived cells in this process has been demonstrated. However, it remains controversial as to whether tumor endothelium...
20.
Zhao F, Sheng Z, Tsai M, Hubbs A, Wang R, OLeary T, et al.
Int Immunol
. 2002 Nov;
14(12):1383-95.
PMID: 12456586
FTL-1, -3 and -10 are three murine day 14 fetal thymocyte cell lines produced in order to model developmental stages within early (CD3-CD4-CD8-) thymocyte differentiation. In this study, we used...