Joachim R Gothert
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Explore the profile of Joachim R Gothert including associated specialties, affiliations and a list of published articles.
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45
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1476
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Recent Articles
1.
Manz K, Heidel F, Koschmieder S, Schlag R, Lipke J, Stegelmann F, et al.
Leukemia
. 2025 Feb;
PMID: 40000843
Myeloproliferative neoplasms (MPN) are associated with a variety of symptoms that severely impact patients' quality of life and ability to perform daily activities. Recent studies showed differences in the perception...
2.
Katagiri D, Nagasaka S, Takahashi K, Wang S, Pozzi A, Zent R, et al.
Sci Rep
. 2024 Nov;
14(1):29179.
PMID: 39587144
The pivotal role of endothelial nitric oxide synthase (eNOS) in diabetic nephropathy (DN) has been demonstrated using global eNOS knockout (eNOSGKO) mice. However, the precise role of endothelially expressed eNOS...
3.
Slowley A, Weinmann S, dEstrube T, Phiri K, Karl F, Gleissner E, et al.
Eur J Haematol
. 2024 Aug;
113(5):704-715.
PMID: 39101601
Objectives: There is limited data on the incidence, prevalence, and treatments for myelofibrosis (MF) in Germany. This retrospective study examined claims data from 3.3 million insured individuals, spanning from 2010...
4.
Isfort S, Manz K, Teichmann L, Crysandt M, Burchert A, Hochhaus A, et al.
Ann Hematol
. 2023 Aug;
102(10):2741-2752.
PMID: 37592092
The approved dose of bosutinib in chronic phase CML is 400 mg QD in first-line and 500 mg QD in later-line treatment. However, given that gastrointestinal (GI) toxicity typically occurs...
5.
Flumann R, Hansen J, Pelzer B, Nieper P, Lohmann T, Kisis I, et al.
Blood Cancer Discov
. 2022 Nov;
4(1):78-97.
PMID: 36346827
Significance: Relapsed/refractory DLBCL remains a major medical challenge, and most of these patients succumb to their disease. Here, we generated mouse models, faithfully recapitulating the biology of MYD88-driven human DLBCL....
6.
Zwiers P, Jongman R, Kuiper T, Moser J, Stan R, Gothert J, et al.
PLoS One
. 2022 Jun;
17(6):e0268986.
PMID: 35675336
Tyrosine-protein kinase receptor Tie2, also known as Tunica interna Endothelial cell Kinase or TEK plays a prominent role in endothelial responses to angiogenic and inflammatory stimuli. Here we generated a...
7.
Gecht J, Tsoukakis I, Kricheldorf K, Stegelmann F, Klausmann M, Griesshammer M, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439237
Inflammation-induced thrombosis represents a severe complication in patients with myeloproliferative neoplasms (MPN) and in those with kidney dysfunction. Overlapping disease-specific attributes suggest common mechanisms involved in MPN pathogenesis, kidney dysfunction,...
8.
Patil A, Gothert J, Khairnar V
Cell Physiol Biochem
. 2020 Aug;
54(4):767-790.
PMID: 32830930
The pandemic of the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 at the end of 2019 marked the third outbreak of a highly pathogenic coronavirus affecting the human population in the...
9.
Bornemann L, Schuster M, Schmitz S, Sobczak C, Bessen C, Merz S, et al.
BMC Cancer
. 2020 Jul;
20(1):650.
PMID: 32660441
Background: The identification of pathologically altered neutrophil granulocyte migration patterns bears strong potential for surveillance and prognostic scoring of diseases. We recently identified a strong correlation between impaired neutrophil motility...
10.
Wass M, Gollner S, Besenbeck B, Schlenk R, Mundmann P, Gothert J, et al.
Leukemia
. 2020 Jun;
35(3):701-711.
PMID: 32561840
All-trans-retinoic acid (ATRA) is highly active in acute promyelocytic leukemia but not in other types of acute myeloid leukemia (AML). Previously, we showed that ATRA in combination with Lysine-specific demethylase...