David A Lomas
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Explore the profile of David A Lomas including associated specialties, affiliations and a list of published articles.
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269
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13526
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Recent Articles
1.
Moll M, Hobbs B, Pratte K, Zhang C, Ghosh A, Bowler R, et al.
medRxiv
. 2025 Jan;
PMID: 39867385
Rationale: Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT deficiency (AATD) suggests inflammatory processes may contribute to...
2.
Gangemi R, Bignotti M, Denardo A, Pearce C, Ronzoni R, Lomas D, et al.
FEBS J
. 2025 Jan;
PMID: 39777987
Neutrophil elastase (NE) is released by activated neutrophils during an inflammatory response and exerts proteolytic activity on elastin and other extracellular matrix components. This protease is rapidly inhibited by the...
3.
Teckman J, Buchanan P, Blomenkamp K, Heyer-Chauhan N, Burling K, Lomas D
Gastro Hep Adv
. 2024 Sep;
3(6):842-850.
PMID: 39280919
Background And Aims: Children with alpha-1-antitrypsin deficiency (AATD) exhibit a wide range of liver disease outcomes from portal hypertension and transplant to asymptomatic without fibrosis. Individual outcomes cannot be predicted....
4.
Suri A, Zhang Z, Neuschwander-Tetri B, Lomas D, Heyer-Chauhan N, Burling K, et al.
Liver Int
. 2024 Sep;
44(12):3204-3213.
PMID: 39263815
Background And Aims: The course of adults with ZZ alpha-1-antitrypsin deficiency (AATD) liver disease is unpredictable. The utility of markers, including liver biopsy, is undefined. Methods: A prospective cohort, including...
5.
Kent D, Ng S, Syanda A, Khoshkenar P, Ronzoni R, Li C, et al.
Hepatology
. 2024 Jul;
81(3):903-916.
PMID: 38954820
Background: Alpha-1 antitrypsin deficiency (A1ATD) is a life-threatening condition caused by the inheritance of the serpin family A member 1 "Z" genetic variant driving alpha-1 antitrypsin (AAT) protein misfolding in...
6.
Kamuda K, Ronzoni R, Majumdar A, Guan F, Irving J, Lomas D
FEBS J
. 2024 Mar;
291(13):2937-2954.
PMID: 38523412
Mutants of alpha-1-antitrypsin cause the protein to self-associate and form ordered aggregates ('polymers') that are retained within hepatocytes, resulting in a predisposition to the development of liver disease. The associated...
7.
Vickers S, Irving J, Lomas D, Thalassinos K
Methods Mol Biol
. 2023 Dec;
2750:41-55.
PMID: 38108966
In this chapter, we describe a method for analyzing both recombinant and plasma-derived alpha 1 antitrypsin and its oligomers by means of native ion mobility mass spectrometry. Our experimental workflow...
8.
Bouton M, Geiger M, Sheffield W, Irving J, Lomas D, Song S, et al.
EMBO Mol Med
. 2023 May;
15(6):e17144.
PMID: 37158379
In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the...
9.
Hayden L, Hobbs B, Busch R, Cho M, Liu M, Lopes-Ramos C, et al.
Respir Res
. 2023 Feb;
24(1):38.
PMID: 36726148
Background: The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining...
10.
Pranke I, Chevalier B, Premchandar A, Baatallah N, Tomaszewski K, Bitam S, et al.
Cell Mol Life Sci
. 2022 Aug;
79(9):503.
PMID: 36045259
Early recognition and enhanced degradation of misfolded proteins by the endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) cause defective protein secretion and membrane targeting, as exemplified for Z-alpha-1-antitrypsin...